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Exploration of nonclinical pharmacodynamics evaluation system of Alzheimer's disease
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Long-jian HUANG1, Chun-yang ZHAO2, Xin-hong FENG3, Jia-qi LAN1, Jing-shu TANG1, Qing-li WANG2, *, Ying PENG1, *
Acta Pharmaceutica Sinica | 2020, 55(5) : 789 - 805
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Acta Pharmaceutica Sinica | 2020, 55(5): 789-805
• Reviews •
Exploration of nonclinical pharmacodynamics evaluation system of Alzheimer's disease
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Long-jian HUANG1, Chun-yang ZHAO2, Xin-hong FENG3, Jia-qi LAN1, Jing-shu TANG1, Qing-li WANG2, *, Ying PENG1, *
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Center for Drug Evaluation, National Medical Product Administration, Beijing 100022, China
  • 3. Department of Neurology, Beijing Tsinghua Changgung Hospital, Beijing 102218, China
Published: 2020-05-12 doi: 10.16438/j.0513-4870.2019-0899
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Alzheimer's disease (AD) is the most common neurodegenerative disease that causes dementia among elderly people. The pathogenesis of AD is still unclear, and currently approved drugs only provide symptomatic benefits and do not prevent or delay progressive neurodegeneration. Meanwhile, potential drugs in development are facing great challenges in clinical translation. Therefore, finding effective treatment for the unmet clinical needs of AD is of great economic value and social significance. In this review, we will summarize the current models and pharmacodynamics evaluation methods of anti-AD drug based on the recent studies at home and abroad, and provide reference for drug development in AD at nonclinical stage.

Alzheimer's disease  /  animal model  /  behavioristics  /  non-clinical pharmacodynamics  /  drug discovery
Long-jian HUANG, Chun-yang ZHAO, Xin-hong FENG, Jia-qi LAN, Jing-shu TANG, Qing-li WANG, Ying PENG. Exploration of nonclinical pharmacodynamics evaluation system of Alzheimer's disease[J]. Acta Pharmaceutica Sinica, 2020 , 55 (5) : 789 -805 . DOI: 10.16438/j.0513-4870.2019-0899
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Article Info
doi: 10.16438/j.0513-4870.2019-0899
  • Receive Date：2019-11-11
  • Online Date：2026-01-21
  • Published：2020-05-12
Article Data
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History
  • Received：2019-11-11
  • Revised：2019-12-06
Funding
Affiliations
    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Center for Drug Evaluation, National Medical Product Administration, Beijing 100022, China
    3. Department of Neurology, Beijing Tsinghua Changgung Hospital, Beijing 102218, China
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光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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