Home Journals Articles Updates About
CN
image
收藏切换
The mechanism of the anti-depression effect of the Radix Bupleuri-Radix Paeoniae Alba herb pair determined by liver metabolomics
收藏切换
PDF
Cong-cong CHEN1, 2, Qi-cai YIN1, 2, Jun-sheng TIAN1, Xiao-xia GAO1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Acta Pharmaceutica Sinica | 2020, 55(5) : 941 - 949
Less
收藏切换
Acta Pharmaceutica Sinica | 2020, 55(5): 941-949
• Original Articles •
The mechanism of the anti-depression effect of the Radix Bupleuri-Radix Paeoniae Alba herb pair determined by liver metabolomics
Full
Cong-cong CHEN1, 2, Qi-cai YIN1, 2, Jun-sheng TIAN1, Xiao-xia GAO1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
Published: 2020-05-12 doi: 10.16438/j.0513-4870.2019-0731
Outline
收藏切换

This study analyzed the effect of the Radix Bupleuri-Radix Paeoniae Alba herb pair on endogenous metabolites in rats with chronic unpredictable mild stress (CUMS)-induced depression by using LC-MS liver metabolomics. Rats were randomly divided into 5 groups:a normal control group, a CUMS model group, a venlafaxine-positive group, and a high-low dose group for the Radix Bupleuri-Radix Paeoniae Alba herb pair, with continuous modeling and administration over 28 days. The efficacy of Radix Bupleuri-Radix Paeoniae Alba herb pair was evaluated by measuring traditional pharmacodynamic indicators of depression (body weight, open field test, sucrose preference test and forced swimming test). Animal experimentation was approved by the Committee on the Ethics of Animal Experiments of Shanxi University (SXULL2016036). Liver metabolic profiles were obtained by the UHPLC-Q Exactive Orbitrap-MS metabolomics technique. The results show that the Radix Bupleuri-Radix Paeoniae Alba herb pair can significantly decrease depression-like behavior of rats in the CUMS model group. Increases in 25 depression-related metabolites were identified by LC-MS metabonomics, and the Radix Bupleuri-Radix Paeoniae Alba herb pair could significantly decrease 16 of them. Metabolic pathway analysis showed that D-glutamine and D-glutamate metabolism, arginine and proline metabolism, alanine, aspartate and glutamate metabolism, and glutathione metabolism were the main metabolic pathways altered by this herb pair in CUMS model rats.

Radix Bupleuri-Radix Paeoniae Alba herb pair  /  chronic unpredictable mild stress  /  liver  /  metabolomics  /  pathway analysis
Cong-cong CHEN, Qi-cai YIN, Jun-sheng TIAN, Xiao-xia GAO, Xue-mei QIN, Guan-hua DU, Yu-zhi ZHOU. The mechanism of the anti-depression effect of the Radix Bupleuri-Radix Paeoniae Alba herb pair determined by liver metabolomics[J]. Acta Pharmaceutica Sinica, 2020 , 55 (5) : 941 -949 . DOI: 10.16438/j.0513-4870.2019-0731
Appendix
Less
Year 2020 volume 55 Issue 5
PDF
119
40
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2019-0731
  • Receive Date：2019-09-07
  • Online Date：2026-01-21
  • Published：2020-05-12
Article Data
Affiliations
History
  • Received：2019-09-07
  • Revised：2019-11-21
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0731
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House