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The role and molecular mechanisms of long noncoding RNAs in cardiac diseases
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Zhen-wei PAN, Bao-feng YANG*
Acta Pharmaceutica Sinica | 2020, 55(5) : 773 - 780
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Acta Pharmaceutica Sinica | 2020, 55(5): 773-780
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The role and molecular mechanisms of long noncoding RNAs in cardiac diseases
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Zhen-wei PAN, Bao-feng YANG*
Affiliations
  • The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Research Unit of Noninfectious Chronic Diseases in Frigid Zone, Chinese Academy of Medical Sciences, Harbin 150081, China
Published: 2020-05-12 doi: 10.16438/j.0513-4870.2020-0099
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Long noncoding RNAs (lncRNAs) are a class of RNAs that are more than 200 nucleotides in length with no protein coding property. LncRNAs are involved in almost every cellular process through multiple mechanisms. LncRNAs can directly bind to molecules in cells such as proteins, RNA, and DNA, to regulate cellular functions by influencing processes including transcription, translation, and molecular transporting. Recent researches showed lncRNAs are key regulators of serious cardiac diseases, especially in development and progression of cardiac ischemia, arrhythmia, cardiac fibrosis, and heart failure. This article mainly summarizes the function and mechanism of lncRNAs in cardiac diseases and gives reasonable prospect of lncRNAs in the future.

long noncoding RNAs  /  heart failure  /  cardiac ischemia  /  arrhythmia  /  myocardial fibrosis  /  biomarker
Zhen-wei PAN, Bao-feng YANG. The role and molecular mechanisms of long noncoding RNAs in cardiac diseases[J]. Acta Pharmaceutica Sinica, 2020 , 55 (5) : 773 -780 . DOI: 10.16438/j.0513-4870.2020-0099
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Article Info
doi: 10.16438/j.0513-4870.2020-0099
  • Receive Date：2020-02-06
  • Online Date：2026-01-21
  • Published：2020-05-12
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  • Received：2020-02-06
  • Revised：2020-03-04
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    The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Research Unit of Noninfectious Chronic Diseases in Frigid Zone, Chinese Academy of Medical Sciences, Harbin 150081, China
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