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Current status and future of non-genomic effects of phytoestrogens
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Xin-yue YANG1, 2, Hai-xin LIU1, 2, 3, Shuang HE1, 2, Rui SHAO1, 2, Yu-xin FENG1, 2, Yan ZHU1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(5) : 854 - 860
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Acta Pharmaceutica Sinica | 2020, 55(5): 854-860
• Reviews •
Current status and future of non-genomic effects of phytoestrogens
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Xin-yue YANG1, 2, Hai-xin LIU1, 2, 3, Shuang HE1, 2, Rui SHAO1, 2, Yu-xin FENG1, 2, Yan ZHU1, 2, *
Affiliations
  • 1. Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • 2. Tianjin International Biomedical Research Institute, Chinese Medicine New Drug Research and Development Center, Tianjin 300457, China
  • 3. Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China
Published: 2020-05-12 doi: 10.16438/j.0513-4870.2019-0959
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Phytoestrogens exhibit various pharmacological estrogen-like effects, such as in the prevention and treatment of osteoporosis, cardiovascular diseases, tumors, etc., but the specific mechanism is still unclear. In recent years, estrogen receptor alpha-mediated rapid non-genomic effects have been identified to play an important role in the pathogenesis of estrogen-related diseases. The research of phytoestrogens exerting pharmacological effects through non-genomic effects has also received increasing attention. This article summarizes the research progress in estrogen receptor alpha-mediated non-genomic effects and analyzes the possible involvement of rapid non-genomic effects in certain pharmacological effects of phytoestrogens. The future prospects of estrogen receptor-mediated non-genomic effects by phytoestrogens are also discussed.

phytoestrogen  /  estradiol  /  nongenomic effect  /  estrogen receptor alpha
Xin-yue YANG, Hai-xin LIU, Shuang HE, Rui SHAO, Yu-xin FENG, Yan ZHU. Current status and future of non-genomic effects of phytoestrogens[J]. Acta Pharmaceutica Sinica, 2020 , 55 (5) : 854 -860 . DOI: 10.16438/j.0513-4870.2019-0959
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Article Info
doi: 10.16438/j.0513-4870.2019-0959
  • Receive Date：2019-11-26
  • Online Date：2026-01-21
  • Published：2020-05-12
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History
  • Received：2019-11-26
  • Revised：2019-12-31
Funding
Affiliations
    1. Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    2. Tianjin International Biomedical Research Institute, Chinese Medicine New Drug Research and Development Center, Tianjin 300457, China
    3. Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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