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Advances in research on HBV inhibitors based on new targets (2): RNase H and others
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Fen-ju WEI1, Yue MA1, Ji YU1, Hai-yong JIA2, Xin-yong LIU1, *, Peng ZHAN1, *
Acta Pharmaceutica Sinica | 2020, 55(4) : 566 - 574
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Acta Pharmaceutica Sinica | 2020, 55(4): 566-574
• Reviews •
Advances in research on HBV inhibitors based on new targets (2): RNase H and others
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Fen-ju WEI1, Yue MA1, Ji YU1, Hai-yong JIA2, Xin-yong LIU1, *, Peng ZHAN1, *
Affiliations
  • 1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
  • 2. School of Pharmacy, Weifang Medical University, Weifang 261053, China
Published: 2020-04-12 doi: 10.16438/j.0513-4870.2019-0711
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Hepatitis B has become one of the major diseases which seriously affect people's health and social development. Hepatitis B, with high incidence and long disease course, cannot be cured by approved drugs such as the nucleoside analogues. Therefore, the discovery of safe and efficient novel HBV inhibitors is of great significance. From the point of view of medicinal chemistry, we summarized and discussed current endeavours towards the discovery and development of anti-HBV agents of RNase H and other novel target inhibitors with various scaffolds or distinct mechanisms of action, besides the existing capsid protein inhibitors.

hepatitis B  /  drug target  /  RNase H  /  inhibitor  /  drug design
Fen-ju WEI, Yue MA, Ji YU, Hai-yong JIA, Xin-yong LIU, Peng ZHAN. Advances in research on HBV inhibitors based on new targets (2): RNase H and others[J]. Acta Pharmaceutica Sinica, 2020 , 55 (4) : 566 -574 . DOI: 10.16438/j.0513-4870.2019-0711
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Year 2020 volume 55 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2019-0711
  • Receive Date：2019-09-02
  • Online Date：2026-01-20
  • Published：2020-04-12
Article Data
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History
  • Received：2019-09-02
  • Revised：2019-10-14
Funding
Affiliations
    1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    2. School of Pharmacy, Weifang Medical University, Weifang 261053, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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