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Advances in research on HBV inhibitors based on new targets (1): capsid protein inhibitors
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Yue MA1, Fen-ju WEI1, Ji YU1, Hai-yong JIA2, Xin-yong LIU1, *, Peng ZHAN1, *
Acta Pharmaceutica Sinica | 2020, 55(4) : 554 - 565
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Acta Pharmaceutica Sinica | 2020, 55(4): 554-565
• Reviews •
Advances in research on HBV inhibitors based on new targets (1): capsid protein inhibitors
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Yue MA1, Fen-ju WEI1, Ji YU1, Hai-yong JIA2, Xin-yong LIU1, *, Peng ZHAN1, *
Affiliations
  • 1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
  • 2. School of Pharmacy, Weifang Medical University, Weifang 261053, China
Published: 2020-04-12 doi: 10.16438/j.0513-4870.2019-0710
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Hepatitis B virus (HBV) capsid protein plays an important role in the life cycle, thus becoming an ideal target for drug design. Capsid protein inhibitors can exert a synergistic antiviral effect with nucleoside drugs by inhibiting the replication of HBV. This paper reviews the research progress of capsid protein inhibitors with different structural types from the perspective of medicinal chemistry.

HBV  /  non-nucleos(t)ide  /  capsid protein inhibitors  /  medicinal chemistry  /  drug target
Yue MA, Fen-ju WEI, Ji YU, Hai-yong JIA, Xin-yong LIU, Peng ZHAN. Advances in research on HBV inhibitors based on new targets (1): capsid protein inhibitors[J]. Acta Pharmaceutica Sinica, 2020 , 55 (4) : 554 -565 . DOI: 10.16438/j.0513-4870.2019-0710
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Article Info
doi: 10.16438/j.0513-4870.2019-0710
  • Receive Date：2019-09-02
  • Online Date：2026-01-20
  • Published：2020-04-12
Article Data
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History
  • Received：2019-09-02
  • Revised：2019-11-12
Funding
Affiliations
    1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    2. School of Pharmacy, Weifang Medical University, Weifang 261053, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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