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Recent advances in the discovery of dengue virus inhibitors
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Ling-xin HOU, Han JU, Peng ZHAN*, Xin-yong LIU*
Acta Pharmaceutica Sinica | 2020, 55(4) : 669 - 678
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Acta Pharmaceutica Sinica | 2020, 55(4): 669-678
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Recent advances in the discovery of dengue virus inhibitors
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Ling-xin HOU, Han JU, Peng ZHAN*, Xin-yong LIU*
Affiliations
  • Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2020-04-12 doi: 10.16438/j.0513-4870.2019-0787
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Dengue fever is one of the most important vector-borne human diseases caused by mosquito vector Aedes aegypti and Aedes albopictus. Dengue virus can cause dengue fever, dengue hemorrhagic fever and dengue shock syndrome. There are no approved drugs for the treatment of dengue disease so far. In this paper, combined with the latest progress in the research of anti-dengue virus, the new progress in the research of anti-dengue virus drugs was reviewed from the aspects of protease inhibitors, virus polymerase inhibitors, entry inhibitors, virus replication-related host factor inhibitors, capsid protein inhibitors and nucleic acid inhibitors.

dengue fever  /  dengue virus  /  dengue hemorrhagic fever  /  drug discovery
Ling-xin HOU, Han JU, Peng ZHAN, Xin-yong LIU. Recent advances in the discovery of dengue virus inhibitors[J]. Acta Pharmaceutica Sinica, 2020 , 55 (4) : 669 -678 . DOI: 10.16438/j.0513-4870.2019-0787
Year 2020 volume 55 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2019-0787
  • Receive Date:2019-09-29
  • Online Date:2026-01-20
  • Published:2020-04-12
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  • Received:2019-09-29
  • Revised:2019-10-17
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    Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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