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Medicinal chemistry strategies in seeking coronavirus inhibitors
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Jing LI1, 2, Xiang-yi JIANG1, 2, Shu-jing XU1, 2, Qing-hua CUI3, Rui-kun DU3, Dong-wei KANG1, 2, Peng ZHAN1, 2, *, Li-jun RONG4, *, Xin-yong LIU1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(4) : 537 - 553
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Acta Pharmaceutica Sinica | 2020, 55(4): 537-553
• Reviews •
Medicinal chemistry strategies in seeking coronavirus inhibitors
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Jing LI1, 2, Xiang-yi JIANG1, 2, Shu-jing XU1, 2, Qing-hua CUI3, Rui-kun DU3, Dong-wei KANG1, 2, Peng ZHAN1, 2, *, Li-jun RONG4, *, Xin-yong LIU1, 2, *
Affiliations
  • 1. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
  • 2. China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan 250012, China
  • 3. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • 4. Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Published: 2020-04-12 doi: 10.16438/j.0513-4870.2020-0131
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The epidemic caused by coronavirus poses a serious threat to human health, but there is no specific drug or vaccine for the treatment of this kind of virus infection. Herein, this article selects typical case studies in recent years and reviews the medicinal chemistry strategies of anti-SARS-CoV, MERS-CoV and other coronavirus drugs from the perspective of medicinal chemistry, and tries to provide some clues to current drug research againstSARS-CoV-2.

coronavirus  /  drug design  /  inhibitors  /  medicinal chemistry strategies
Jing LI, Xiang-yi JIANG, Shu-jing XU, Qing-hua CUI, Rui-kun DU, Dong-wei KANG, Peng ZHAN, Li-jun RONG, Xin-yong LIU. Medicinal chemistry strategies in seeking coronavirus inhibitors[J]. Acta Pharmaceutica Sinica, 2020 , 55 (4) : 537 -553 . DOI: 10.16438/j.0513-4870.2020-0131
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Article Info
doi: 10.16438/j.0513-4870.2020-0131
  • Receive Date：2020-02-16
  • Online Date：2026-01-20
  • Published：2020-04-12
Article Data
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History
  • Received：2020-02-16
  • Revised：2020-02-24
Funding
Affiliations
    1. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    2. China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan 250012, China
    3. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    4. Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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