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New progress in medicinal chemistry of anti-poxvirus drugs research
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Tao ZHANG, Zhong-xia ZHOU, Peng ZHAN*, Xin-yong LIU*
Acta Pharmaceutica Sinica | 2020, 55(4) : 734 - 743
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Acta Pharmaceutica Sinica | 2020, 55(4): 734-743
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New progress in medicinal chemistry of anti-poxvirus drugs research
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Tao ZHANG, Zhong-xia ZHOU, Peng ZHAN*, Xin-yong LIU*
Affiliations
  • Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2020-04-12 doi: 10.16438/j.0513-4870.2019-0954
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Poxvirus is the largest and most complex virus of the known virions, and the main pathogenicity to humans is Orthopoxvirus. In recent years, with the deep understanding of the biological structure and replication cycle of Orthopoxvirus, new small molecular compounds with high efficiency and low toxicity have been discovered as new drugs, and some have entered the clinical trial stage. This article summarizes the research progress of poxvirus inhibitors with different targets.

poxvirus  /  Orthopoxvirus  /  inhibitor  /  target  /  drug design
Tao ZHANG, Zhong-xia ZHOU, Peng ZHAN, Xin-yong LIU. New progress in medicinal chemistry of anti-poxvirus drugs research[J]. Acta Pharmaceutica Sinica, 2020 , 55 (4) : 734 -743 . DOI: 10.16438/j.0513-4870.2019-0954
Year 2020 volume 55 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2019-0954
  • Receive Date:2019-11-26
  • Online Date:2026-01-20
  • Published:2020-04-12
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  • Received:2019-11-26
  • Revised:2019-12-17
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    Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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