Home Journals Articles Updates About
CN
image
收藏切换
Research progress of cGAS-STING in tumor metastasis
收藏切换
PDF
Shu-mei TU1, 2, Yu-ping LIU1, 2, Yan CHEN1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(3) : 398 - 406
Less
收藏切换
Acta Pharmaceutica Sinica | 2020, 55(3): 398-406
• Reviews •
Research progress of cGAS-STING in tumor metastasis
Full
Shu-mei TU1, 2, Yu-ping LIU1, 2, Yan CHEN1, 2, *
Affiliations
  • 1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
  • 2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
Published: 2020-03-12 doi: 10.16438/j.0513-4870.2019-0721
Outline
收藏切换

Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING) signaling pathway as an essential immune response pathway in cytoplasm, can find cytoplasmic DNA to regulate the innate immune and adaptive immune response. Studies have shown that the signaling pathway can be activated by both tumor self-DNA and genomic instability, thus to promote or inhibit the development and metastasis of tumors. Therefore, the role of cGAS-STING in tumor genesis, development and metastasis will be systematically expounded from the structures, physiological functions, inhibitors and agonists of cGAS and STING as well as its pathway transduction regulation in this paper. The paper aims to offer theoretical basis and reference for targeting cGAS-STING anti-tumor drugs in clinical practice and cancer clinical and cancer research workers.

cGAS-STING  /  DNA  /  tumor  /  metastasis  /  immune  /  agonist  /  inhibitor
Shu-mei TU, Yu-ping LIU, Yan CHEN. Research progress of cGAS-STING in tumor metastasis[J]. Acta Pharmaceutica Sinica, 2020 , 55 (3) : 398 -406 . DOI: 10.16438/j.0513-4870.2019-0721
Appendix
Less
Year 2020 volume 55 Issue 3
PDF
165
61
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2019-0721
  • Receive Date：2019-09-06
  • Online Date：2026-01-20
  • Published：2020-03-12
Article Data
Affiliations
History
  • Received：2019-09-06
  • Revised：2019-10-18
Funding
Affiliations
    1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
    2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0721
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House