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Research progress in drugs for treating sepsis
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Chun-yang XIE, Xiu-kun WANG, Xue-fu YOU*
Acta Pharmaceutica Sinica | 2020, 55(3) : 413 - 420
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Acta Pharmaceutica Sinica | 2020, 55(3): 413-420
• Reviews •
Research progress in drugs for treating sepsis
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Chun-yang XIE, Xiu-kun WANG, Xue-fu YOU*
Affiliations
  • Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2020-03-12 doi: 10.16438/j.0513-4870.2019-0758
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Sepsis is a refractory disease with high mortality in which the host's immune response to the infection is dysfunctional, resulting in life-threatening organ function damage. The pathogenesis of sepsis is complex, involving systemic inflammation, immunosuppressive and coagulation abnormalities, and endothelial barrier damage caused by the infecting pathogenic microorganisms and their toxins. The pathogenesis of sepsis is closely related to multiple systems disorder and multiple organ dysfunction and failure. In recent years, the incidence of sepsis has been increasing globally, with an annual increase of 9%. Since the development of sepsis does not depend on the infecting pathogenic microorganisms and the late inflammatory reaction can be life-threatening, clinical treatment of sepsis can be very difficult. However, the current antibiotic treatments for sepsis are not ideal. Most clinical treatments are not curative, so researchers seek new drug designs based on exploring molecular mechanisms of the pathophysiological process in sepsis patients. This paper reviews the recent development of drugs designed according to the sepsis pathophysiological process.

sepsis  /  septic shock  /  pathophysiological process  /  target  /  drug therapy
Chun-yang XIE, Xiu-kun WANG, Xue-fu YOU. Research progress in drugs for treating sepsis[J]. Acta Pharmaceutica Sinica, 2020 , 55 (3) : 413 -420 . DOI: 10.16438/j.0513-4870.2019-0758
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Article Info
doi: 10.16438/j.0513-4870.2019-0758
  • Receive Date：2019-09-16
  • Online Date：2026-01-20
  • Published：2020-03-12
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History
  • Received：2019-09-16
  • Revised：2019-12-16
Funding
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    Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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