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Advances in research on the role of nitric oxide in regulating sleep and arousal
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Feng-ting YU, Jian-jun ZHANG*
Acta Pharmaceutica Sinica | 2020, 55(3) : 421 - 426
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Acta Pharmaceutica Sinica | 2020, 55(3): 421-426
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Advances in research on the role of nitric oxide in regulating sleep and arousal
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Feng-ting YU, Jian-jun ZHANG*
Affiliations
  • Beijing Key Laboratory of New Drug Mechanism and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2020-03-12 doi: 10.16438/j.0513-4870.2019-0790
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Nitric oxide (NO) is widely present in peripheral and central nervous system and regulates many physiological functions. Sleep-arousal is an advanced physiological activity. Studies have shown that NO is involved in the regulation of sleep and arousal. Nitric oxide synthases (NOSs) are a family of enzymes that catalyze the production of NO from L-arginine. Through guanylate cyclase or S-nitrosation of protein, NO can affect the activity of the ascending reticular activating system to regulate the sleep-arousal process. This paper summarizes the production of NO, its effect on sleep-arousal and its mechanism in the ascending reticular activating system, and provides new ideas and directions for the study of sleep and arousal.

sleep  /  arousal  /  nitric oxide  /  ascending reticular activating system
Feng-ting YU, Jian-jun ZHANG. Advances in research on the role of nitric oxide in regulating sleep and arousal[J]. Acta Pharmaceutica Sinica, 2020 , 55 (3) : 421 -426 . DOI: 10.16438/j.0513-4870.2019-0790
Year 2020 volume 55 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2019-0790
  • Receive Date:2019-09-30
  • Online Date:2026-01-20
  • Published:2020-03-12
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  • Received:2019-09-30
  • Revised:2019-12-16
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    Beijing Key Laboratory of New Drug Mechanism and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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