Home Journals Articles Updates About
CN
image
收藏切换
Effects of Guilingji on serum metabolites in D-galactose-induced aging in rats
收藏切换
PDF
Xiao-ling YANG1, Si-jun ZHAO1, 3, Jun-sheng TIAN1, Bin ZHANG2, Pei-yi WANG2, Xiao-xia GAO1, *, Xue-mei QIN1, *
Acta Pharmaceutica Sinica | 2020, 55(2) : 315 - 322
Less
收藏切换
Acta Pharmaceutica Sinica | 2020, 55(2): 315-322
• Original Articles •
Effects of Guilingji on serum metabolites in D-galactose-induced aging in rats
Full
Xiao-ling YANG1, Si-jun ZHAO1, 3, Jun-sheng TIAN1, Bin ZHANG2, Pei-yi WANG2, Xiao-xia GAO1, *, Xue-mei QIN1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. Shanxi Guang Yuyuan Traditional Chinese Medicine Co., Ltd., Taigu 030800, China
  • 3. Shanxi Food and Drug Inspection Institute, Taiyuan 030006, China
Published: 2020-02-12 doi: 10.16438/j.0513-4870.2019-0622
Outline
收藏切换

This work investigates the effects of Guilingji (GLJ) on D-galactose-induced aging and changes in serum metabolites by UHPLC-Q exactive orbitrap-MS in rats. The rat model of aging by subcutaneous injection of D-galactose (300 mg·kg-1) was used to analyze the effect of different concentrations of GLJ (37.5, 75, 150 mg·kg-1) on an open field test in aging rats. Rat serum was collected after 8 weeks and subjected to LC-MS to analyze the anti-aging effect of GLJ. Animal experimentation was approved according to the Committee on the Ethics of Animal Experiments of Shanxi University (SXULL2014032). GLJ significantly improved the autonomous activity of rats. Compared with the control group, 23 metabolites in the treated group changed significantly, involving three main pathways. The group that was given GLJ had altered regulation of 4 serum metabolites in two pathways. Our results indicate that GLJ can delay aging behavior in rats; the mechanism of this anti-ageing effect remains to be determined.

Guilingji  /  delaying senescence  /  open field test  /  LC-MS  /  metabolomics
Xiao-ling YANG, Si-jun ZHAO, Jun-sheng TIAN, Bin ZHANG, Pei-yi WANG, Xiao-xia GAO, Xue-mei QIN. Effects of Guilingji on serum metabolites in D-galactose-induced aging in rats[J]. Acta Pharmaceutica Sinica, 2020 , 55 (2) : 315 -322 . DOI: 10.16438/j.0513-4870.2019-0622
Appendix
Less
Year 2020 volume 55 Issue 2
PDF
177
75
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2019-0622
  • Receive Date：2019-08-31
  • Online Date：2026-01-20
  • Published：2020-02-12
Article Data
Affiliations
History
  • Received：2019-08-31
  • Revised：2019-11-22
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. Shanxi Guang Yuyuan Traditional Chinese Medicine Co., Ltd., Taigu 030800, China
    3. Shanxi Food and Drug Inspection Institute, Taiyuan 030006, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0622
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House