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A new alkaloid from Rehmanniae Radix Preparata
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Jin-jin Lü1, 2, Jing-ke ZHANG1, 2, Bei-bei ZHANG1, 2, Juan-juan LIU1, 2, Meng LI1, 2, Jing-ya SHI1, 2, Deng-hui ZHU1, 2, Hang YANG1, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(2) : 289 - 293
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Acta Pharmaceutica Sinica | 2020, 55(2): 289-293
• Original Articles •
A new alkaloid from Rehmanniae Radix Preparata
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Jin-jin Lü1, 2, Jing-ke ZHANG1, 2, Bei-bei ZHANG1, 2, Juan-juan LIU1, 2, Meng LI1, 2, Jing-ya SHI1, 2, Deng-hui ZHU1, 2, Hang YANG1, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Affiliations
  • 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Diagnosis by Henan and Education Ministry of P. R. China, Zhengzhou 450046, China
Published: 2020-02-12 doi: 10.16438/j.0513-4870.2019-0716
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The chemical constituents of Rehmanniae Radix Preparata were prepared according to the traditional method of "jiu zheng jiu shai" and investigated using multiple chromatographic methods. Six alkaloids were isolated and their structures were elucidated from spectral data and physicochemical properties, as follows:rehmanniae alkaloid A (4-{[(5-O-á-D-galactopyranosyloxy)methyl]-1H-pyrrole-2-carbaldehyde-1-yl}butyric acidmethyl ester) (1), baimantuoluoamide B (2), capparisine C (3), harman-3-carboxylic acid (4), (2S)-1-[2-(furan-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carboxylate (5), and 1-[2-(furan-2-yl)-2-oxoethyl]pyrrolidin-2-one (6). Among them, compound 1 is a new alkaloid. Compounds 2-6 were newly isolated from Rehmannia glutinosa Libosch. The effect of compounds 1-6 on NRK-52e cell injury induced by LPS was investigated. The results show that compounds 1-3 exhibit protective effects against LPS-induced damage to NRK-52e cells.

Rehmanniae Radix Preparata  /  chemical compositions  /  alkaloids  /  NRK-52e cells  /  RTCA
Jin-jin Lü, Jing-ke ZHANG, Bei-bei ZHANG, Juan-juan LIU, Meng LI, Jing-ya SHI, Deng-hui ZHU, Hang YANG, Xiao-ke ZHENG, Wei-sheng FENG. A new alkaloid from Rehmanniae Radix Preparata[J]. Acta Pharmaceutica Sinica, 2020 , 55 (2) : 289 -293 . DOI: 10.16438/j.0513-4870.2019-0716
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Year 2020 volume 55 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2019-0716
  • Receive Date：2019-09-04
  • Online Date：2026-01-20
  • Published：2020-02-12
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History
  • Received：2019-09-04
  • Revised：2019-10-12
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Affiliations
    1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Diagnosis by Henan and Education Ministry of P. R. China, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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