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The key role of mitochondrial energy metabolism disorder in the pathogenesis of depression
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Shao-bo LIU1, Ting LING-HU1, Yao GAO1, Jun-sheng TIAN1, 2, *, Xue-mei QIN1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(2) : 195 - 200
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Acta Pharmaceutica Sinica | 2020, 55(2): 195-200
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The key role of mitochondrial energy metabolism disorder in the pathogenesis of depression
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Shao-bo LIU1, Ting LING-HU1, Yao GAO1, Jun-sheng TIAN1, 2, *, Xue-mei QIN1, 2, *
Affiliations
  • 1. Modern Research Center of Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. Key Laboratory of Research and Utilization of Functional Substances in Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
Published: 2020-02-12 doi: 10.16438/j.0513-4870.2019-0623
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Depression is a common mental illness with mood disorders as the main clinical feature. In recent years numerous studies have shown that mitochondrial function and structure are abnormal in patients with depression, and changes in mitochondrial ultrastructure can lead to energy metabolism disorders in the body. It is suggested that 'mitochondrial energy metabolism disorder' may be the pathogenesis of depression. This paper reviews the intrinsic association of mitochondrial energy metabolism with depression and notes potential mechanisms from the standpoint of mitochondrial structure and function on the molecular level. We provide a reference for understanding the pathogenesis of depression and identifying the possible targets of antidepressant drugs.

depression  /  mitochondria  /  energy metabolism disorder  /  pathogenesis
Shao-bo LIU, Ting LING-HU, Yao GAO, Jun-sheng TIAN, Xue-mei QIN. The key role of mitochondrial energy metabolism disorder in the pathogenesis of depression[J]. Acta Pharmaceutica Sinica, 2020 , 55 (2) : 195 -200 . DOI: 10.16438/j.0513-4870.2019-0623
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Article Info
doi: 10.16438/j.0513-4870.2019-0623
  • Receive Date：2019-08-01
  • Online Date：2026-01-20
  • Published：2020-02-12
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  • Received：2019-08-01
  • Revised：2019-10-10
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Affiliations
    1. Modern Research Center of Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. Key Laboratory of Research and Utilization of Functional Substances in Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
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