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The key to fine manufacturing of liquid polyphenol preparations: the principle of multi-precipitation with steady-state reconstruction
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Hao-zhou HUANG1, Fei RAN1, Jun-zhi LIN2, Meng-qi LI3, Wen-quan ZOU4, San-hu FAN5, Ming YANG6, Run-chun XU1, Li HAN1, *, Ding-kun ZHANG1, *
Acta Pharmaceutica Sinica | 2020, 55(1) : 45 - 53
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Acta Pharmaceutica Sinica | 2020, 55(1): 45-53
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The key to fine manufacturing of liquid polyphenol preparations: the principle of multi-precipitation with steady-state reconstruction
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Hao-zhou HUANG1, Fei RAN1, Jun-zhi LIN2, Meng-qi LI3, Wen-quan ZOU4, San-hu FAN5, Ming YANG6, Run-chun XU1, Li HAN1, *, Ding-kun ZHANG1, *
Affiliations
  • 1. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of TCM, Chengdu 611137, China
  • 2. Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
  • 3. Sichuan Nursing Vocational College, Chengdu 610100, China
  • 4. College of Chemistry, Sichuan University, Chengdu 610064, China
  • 5. Sanajon Pharmaceutical Group, Chengdu 610000, China
  • 6. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Published: 2020-01-12 doi: 10.16438/j.0513-4870.2019-0567
Outline
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Plant polyphenols have a wide range of pharmacological activities and application prospects. Liquid polyphenol preparations have special physical phases and complex chemical compositions, with problems such as poor stability and easy precipitation during production and marketing. Taking the multi-precipitation mechanism of plant polyphenol liquid preparations as an example, we discuss the chemistry and composition of the precipitation, how it forms, whether precipitationcan be controlled, and the interaction law of three precipitation approaches. An unstable mechanism model is proposed where hydrolyzed tannin hydrolysis and catechin non-enzymatic oxidative polymerization repeatedly induces associative colloid aggregation and precipitation. This study explains the complex physicochemical changes in polyphenol solutions and the microcosmic mechanism of instability in the induced system and proposes a steady state reconstruction of liquid polyphenol preparation consistent with the common law of precipitation and control. It has scientific significance for promoting the development and manufacture of high quality liquid polyphenol preparations.

polyphenol  /  liquid preparation  /  colloid  /  fine manufacturing  /  precipitation  /  self-assembly
Hao-zhou HUANG, Fei RAN, Jun-zhi LIN, Meng-qi LI, Wen-quan ZOU, San-hu FAN, Ming YANG, Run-chun XU, Li HAN, Ding-kun ZHANG. The key to fine manufacturing of liquid polyphenol preparations: the principle of multi-precipitation with steady-state reconstruction[J]. Acta Pharmaceutica Sinica, 2020 , 55 (1) : 45 -53 . DOI: 10.16438/j.0513-4870.2019-0567
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Article Info
doi: 10.16438/j.0513-4870.2019-0567
  • Receive Date：2019-07-16
  • Online Date：2026-01-20
  • Published：2020-01-12
Article Data
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History
  • Received：2019-07-16
  • Revised：2019-09-30
Funding
Affiliations
    1. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of TCM, Chengdu 611137, China
    2. Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
    3. Sichuan Nursing Vocational College, Chengdu 610100, China
    4. College of Chemistry, Sichuan University, Chengdu 610064, China
    5. Sanajon Pharmaceutical Group, Chengdu 610000, China
    6. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
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https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0567
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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