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Physiologically based pharmacokinetic modeling for children and its application in pediatric drug research
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Xiao-jie ZHENG1, Si-ze LI2, Ya-wen YUAN2, Sha-sha JIN2, Min LI2, Xiao-qiang XIANG2, *
Acta Pharmaceutica Sinica | 2020, 55(1) : 38 - 44
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Acta Pharmaceutica Sinica | 2020, 55(1): 38-44
• Reviews •
Physiologically based pharmacokinetic modeling for children and its application in pediatric drug research
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Xiao-jie ZHENG1, Si-ze LI2, Ya-wen YUAN2, Sha-sha JIN2, Min LI2, Xiao-qiang XIANG2, *
Affiliations
  • 1. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. School of Pharmacy, Fudan University, Shanghai 201203, China
Published: 2020-01-12 doi: 10.16438/j.0513-4870.2019-0594
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Physiologically based pharmacokinetic (PBPK) modeling is an important tool to predict pharmacokinetic or pharmacodynamic profiles in special populations, especially in children and infants where designing and conducting clinical studies is difficult. The application of PBPK modeling can effectively promote the development of pediatric drugs and their clinical use. At present, PBPK modeling of pediatric populations is mainly applied in clinical trial design, drug-drug interaction (DDI) risk assessment, and dose selection in children. This review discusses the advantages of PBPK modeling in pediatric drug research and summarizes how to extrapolate a PBPK model from adults to children. The theoretical basis for pediatric PBPK models, the modelling process and important physiological parameters during the modeling process are introduced. Some successful applications of PBPK modeling in pediatric drug research and development are also presented. This review also analyzes the current limitations and future directions of pediatric PBPK modeling.

pediatric drug  /  physiologically based pharmacokinetic modeling  /  drug-drug interaction
Xiao-jie ZHENG, Si-ze LI, Ya-wen YUAN, Sha-sha JIN, Min LI, Xiao-qiang XIANG. Physiologically based pharmacokinetic modeling for children and its application in pediatric drug research[J]. Acta Pharmaceutica Sinica, 2020 , 55 (1) : 38 -44 . DOI: 10.16438/j.0513-4870.2019-0594
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Article Info
doi: 10.16438/j.0513-4870.2019-0594
  • Receive Date：2019-07-23
  • Online Date：2026-01-20
  • Published：2020-01-12
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  • Received：2019-07-23
  • Revised：2019-10-11
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    1. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. School of Pharmacy, Fudan University, Shanghai 201203, China
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表12种不同金属材料的力学参数
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Number of
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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