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Concentration-dependent effects of nitric oxide on tumors and chemosensitivity
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Hui-lan LI1, Yi JIN1, Yuan-ting MAO1, Guo-liang XU2, *, Yuan-ying FANG1, *
Acta Pharmaceutica Sinica | 2020, 55(1) : 33 - 37
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Acta Pharmaceutica Sinica | 2020, 55(1): 33-37
• Reviews •
Concentration-dependent effects of nitric oxide on tumors and chemosensitivity
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Hui-lan LI1, Yi JIN1, Yuan-ting MAO1, Guo-liang XU2, *, Yuan-ying FANG1, *
Affiliations
  • 1. National Engineering Research Center for the Manufacturing Technology of Solid Chinese Medicine, Jiangxi University of TCM, Nanchang 330004, China
  • 2. Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of TCM, Nanchang 330004, China
Published: 2020-01-12 doi: 10.16438/j.0513-4870.2019-0491
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The resistance and dose limitation of tumors is a serious obstacle to cytotoxic drug therapy in the field of medical oncology. Nitric oxide (NO) is a powerful adjuvant for tumor hypersensitivity for traditional chemotherapy and radiation therapy. The concentration of NO plays an important role in affecting its anti-tumor effect. This review summarizes the mechanism of concentration-dependent effects of NO on tumor cells and the mechanism of chemotherapy sensitization. It provides evidence for rational use of NO to exert anti-tumor effects, and overcoming multidrug resistance and anti-tumor drug development.

nitric oxide  /  tumor  /  concentration  /  mechanism  /  chemotherapy sensitization
Hui-lan LI, Yi JIN, Yuan-ting MAO, Guo-liang XU, Yuan-ying FANG. Concentration-dependent effects of nitric oxide on tumors and chemosensitivity[J]. Acta Pharmaceutica Sinica, 2020 , 55 (1) : 33 -37 . DOI: 10.16438/j.0513-4870.2019-0491
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Article Info
doi: 10.16438/j.0513-4870.2019-0491
  • Receive Date：2019-06-20
  • Online Date：2026-01-20
  • Published：2020-01-12
Article Data
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History
  • Received：2019-06-20
  • Revised：2019-08-12
Funding
Affiliations
    1. National Engineering Research Center for the Manufacturing Technology of Solid Chinese Medicine, Jiangxi University of TCM, Nanchang 330004, China
    2. Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of TCM, Nanchang 330004, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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