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Research situation of pH low insertion peptides
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Xue-li JIA1, Jia ZHANG1, Ting ZHAO1, Qing DU1, De-ying CAO1, Bai XIANG1, *, Ge-xia GENG2, *, Xian-rong QI3
Acta Pharmaceutica Sinica | 2018, 53(3) : 375 - 382
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Acta Pharmaceutica Sinica | 2018, 53(3): 375-382
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Research situation of pH low insertion peptides
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Xue-li JIA1, Jia ZHANG1, Ting ZHAO1, Qing DU1, De-ying CAO1, Bai XIANG1, *, Ge-xia GENG2, *, Xian-rong QI3
Affiliations
  • 1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
  • 2. Hebei Center For Food And Drug Evaluation and Certification, Shijiazhuang 050091, China
  • 3. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Published: 2018-03-12 doi: 10.16438/j.0513-4870.2017-0830
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Extracellular acidity has been associated with many pathological states, such as cancer, ischemic stroke, neurotrauma and infection, which makes it an effective target for therapy and diagnosis of such diseases. As a polypeptide vector, pH low insertion peptides (pHLIPs) are endowed with high sensitivity to extracellular acidic environment, which can insert the membrane and deliver payload to pathological cells in a pH dependent manner. Here, theranostic applications of pHLIP in disease, are reviewed in two aspects:pHLIP-mediated single-molecule transporter and nano-sized carrier.

pH low insertion peptide  /  extracellular acidic environment  /  theranostic  /  tumor  /  nano-sized carrier
Xue-li JIA, Jia ZHANG, Ting ZHAO, Qing DU, De-ying CAO, Bai XIANG, Ge-xia GENG, Xian-rong QI. Research situation of pH low insertion peptides[J]. Acta Pharmaceutica Sinica, 2018 , 53 (3) : 375 -382 . DOI: 10.16438/j.0513-4870.2017-0830
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Article Info
doi: 10.16438/j.0513-4870.2017-0830
  • Receive Date：2017-08-30
  • Online Date：2026-01-15
  • Published：2018-03-12
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History
  • Received：2017-08-30
  • Revised：2017-10-23
Funding
Affiliations
    1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
    2. Hebei Center For Food And Drug Evaluation and Certification, Shijiazhuang 050091, China
    3. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
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小菇属 Mycena 11 5.26
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红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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