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The effects of catechin on inflammatory response induced by lipopolysaccharide in BV-2 cells
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Qing WANG1, Zhe-lin JIA2, Li-juan SONG1, Jie-zhong YU3, Zhi-chao YANG1, Wei-jia JIANG1, Bao-guo XIAO4, Cun-gen MA1, 3, *
Acta Pharmaceutica Sinica | 2018, 53(2) : 244 - 248
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Acta Pharmaceutica Sinica | 2018, 53(2): 244-248
• ORIGINAL ARTICLES •
The effects of catechin on inflammatory response induced by lipopolysaccharide in BV-2 cells
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Qing WANG1, Zhe-lin JIA2, Li-juan SONG1, Jie-zhong YU3, Zhi-chao YANG1, Wei-jia JIANG1, Bao-guo XIAO4, Cun-gen MA1, 3, *
Affiliations
  • 1. The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, China
  • 2. First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China
  • 3. Institute of Brain Science, Shanxi Datong University, Datong 037009, China
  • 4. Institute of Neurology, Fudan University, Shanghai 200040, China
Published: 2018-02-12 doi: 10.16438/j.0513-4870.2017-0993
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The effects of catechin on inflammatory response of BV-2 cells were investigated using the lipopolysaccharide (LPS) model. BV-2 cells were incubated with LPS (1 mg·L-1) for 12 h in the microglia inflammatory model in vitro. After catechin and LPS co-incubation for 12 h, MTT, ELISA and Western blot were used to detect cell viability, cytokines, cell migration and protein expression. In addition, transwell assay was conducted to investigate the effect of catechin on cell chemokaxis. Catechin did not show any cytotoxicity effect on BV-2 cells, but reversed the change in cell morphology and inhibited the release of TNF-α and IL-1β, cell chemotaxis and phosphorylation of NF-κB/p65. In conclusion, Catechin could inhibit the LPS-induced inflammatory response in BV-2 cells.

catechin  /  lipopolysaccharide  /  BV-2 cell  /  inflammatory response
Qing WANG, Zhe-lin JIA, Li-juan SONG, Jie-zhong YU, Zhi-chao YANG, Wei-jia JIANG, Bao-guo XIAO, Cun-gen MA. The effects of catechin on inflammatory response induced by lipopolysaccharide in BV-2 cells[J]. Acta Pharmaceutica Sinica, 2018 , 53 (2) : 244 -248 . DOI: 10.16438/j.0513-4870.2017-0993
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Article Info
doi: 10.16438/j.0513-4870.2017-0993
  • Receive Date：2017-10-11
  • Online Date：2026-01-15
  • Published：2018-02-12
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History
  • Received：2017-10-11
  • Accepted：2017-11-18
Funding
Affiliations
    1. The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, China
    2. First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China
    3. Institute of Brain Science, Shanxi Datong University, Datong 037009, China
    4. Institute of Neurology, Fudan University, Shanghai 200040, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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