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Preparation of matrine loaded microspheres based on Bletilla striata polysaccharide
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Wei-ze LI1, 2, *, Ning ZHAO1, 2, Zhuo CHEN1, 2, Wen-xia HAN1, Li-na FU1, 2, Shu-miao HE1, Wen-bo FU1, Sheng-sheng HE1, Jian LI1
Acta Pharmaceutica Sinica | 2018, 53(2) : 284 - 290
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Acta Pharmaceutica Sinica | 2018, 53(2): 284-290
• ORIGINAL ARTICLES •
Preparation of matrine loaded microspheres based on Bletilla striata polysaccharide
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Wei-ze LI1, 2, *, Ning ZHAO1, 2, Zhuo CHEN1, 2, Wen-xia HAN1, Li-na FU1, 2, Shu-miao HE1, Wen-bo FU1, Sheng-sheng HE1, Jian LI1
Affiliations
  • 1. School of Pharmacy, Xi'an Medical University, Xi'an 710021, China
  • 2. Institute of Medicine, Xi'an Medical University, Xi'an 710021, China
Published: 2018-02-12 doi: 10.16438/j.0513-4870.2017-0903
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Microspheres (MS) are an excellent transarterial chemoembolization carrier for cancer treatment. Then the Bletilla striata polysaccharide (BSP) that was isolated from the rattan of Bletilla striata was used as skeleton material, and the matrine (ME) loaded Bletilla striata polysaccharide microspheres (ME-BSPMS) were prepared by emulsify-chemical crosslinking method. ME-BSPMS was characterized for appearance shape, particle size, drug loading, swelling ratio, suspension property, drug entrapment condition and in vitro release characteristics. The results showed that the ME-BSPMS appeared as round spherical and smooth shape by SEM, with an average size of (85 ±7) μm. ME-BSPMS with a good suspension in physiological saline and the swelling ratio could reach upwards of (53 ±4.2)% in 20 minutes, also with a large amount of drug loading of (30.12 ±3.25)%. The results of DSC scanning indicate that good compatibility exists between the ME and BSP, and the ME could be embedded fully in the matrix of the ME-BSPMS. The accumulation drug release from ME-BSPMS was (25.38 ±1.57)% at 12 h, this suggests that the ME-BSPMS has a good sustained release effect. These results indicate that the ME-BSPMS may be a promising transarterial chemoembolization carrier for cancer treatment.

Bletilla striata polysaccharide  /  matrine  /  transarterial chemoembolization  /  microsphere  /  preparation property
Wei-ze LI, Ning ZHAO, Zhuo CHEN, Wen-xia HAN, Li-na FU, Shu-miao HE, Wen-bo FU, Sheng-sheng HE, Jian LI. Preparation of matrine loaded microspheres based on Bletilla striata polysaccharide[J]. Acta Pharmaceutica Sinica, 2018 , 53 (2) : 284 -290 . DOI: 10.16438/j.0513-4870.2017-0903
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Article Info
doi: 10.16438/j.0513-4870.2017-0903
  • Receive Date：2017-09-12
  • Online Date：2026-01-15
  • Published：2018-02-12
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History
  • Received：2017-09-12
  • Accepted：2017-10-09
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Affiliations
    1. School of Pharmacy, Xi'an Medical University, Xi'an 710021, China
    2. Institute of Medicine, Xi'an Medical University, Xi'an 710021, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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