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Identification of metabolites of Reduning injection in rat plasma, bile, urine and feces after intravenous administration
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Chun-xue WANG1, Ling WANG2, Da-wei QIAN1, *, Huang-qin ZHANG3, Wen-zhe HUANG4, Tuan-jie WANG4, Zhen-hua ZHU2, Shu-lan SU3, Sheng GUO3, Jin-ao DUAN2
Acta Pharmaceutica Sinica | 2018, 53(7) : 1148 - 1155
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Acta Pharmaceutica Sinica | 2018, 53(7): 1148-1155
• ORIGINAL ARTICLES·Pharmaceutical Analysis •
Identification of metabolites of Reduning injection in rat plasma, bile, urine and feces after intravenous administration
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Chun-xue WANG1, Ling WANG2, Da-wei QIAN1, *, Huang-qin ZHANG3, Wen-zhe HUANG4, Tuan-jie WANG4, Zhen-hua ZHU2, Shu-lan SU3, Sheng GUO3, Jin-ao DUAN2
Affiliations
  • 1. Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 3. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 4. Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
Published: 2018-07-12 doi: 10.16438/j.0513-4870.2018-0052
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This study was designed to determine the metabolites of Renduining injection in rats. The ultra-high performance liquid chromatography-LTQ Orbitrap mass spectrometric (UHPLC-LTQ-Orbitrap-MS) and mass defect filter techniques were applied to analyze the metabolites of Reduning injection in rat plasma, bile, urine and feces. As a result, we determined 14 metabolites of geniposide, including oxidation, dehydration, hydroxymethylene loss, hydrolysis, ring-opened, cysteine conjugation and glucuronidation conjugation of aglycone; 9 metabolites of geniposidic acid, consisting of dehydration, ring-opened, double-bond reduction and cysteine conjugation; 6 metabolites of secoxylogain including hydrolysis, hydroxymethylene loss, hydroxylation and ethylation; 12 metabolites of chlorogenic acid, containing decarboxylation, hydrolysis, methylation, acetylation, cysteinylglycine conjugation and glutathione conjugation. It provided information for the therapeutic effect of Reduning in vivo.

Reduning injection  /  geniposide  /  geniposidic acid  /  secoxylogain  /  chlorogenic acid  /  metabolite
Chun-xue WANG, Ling WANG, Da-wei QIAN, Huang-qin ZHANG, Wen-zhe HUANG, Tuan-jie WANG, Zhen-hua ZHU, Shu-lan SU, Sheng GUO, Jin-ao DUAN. Identification of metabolites of Reduning injection in rat plasma, bile, urine and feces after intravenous administration[J]. Acta Pharmaceutica Sinica, 2018 , 53 (7) : 1148 -1155 . DOI: 10.16438/j.0513-4870.2018-0052
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Article Info
doi: 10.16438/j.0513-4870.2018-0052
  • Receive Date：2018-01-13
  • Online Date：2026-01-15
  • Published：2018-07-12
Article Data
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History
  • Received：2018-01-13
  • Revised：2018-03-16
Funding
Affiliations
    1. Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
    3. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
    4. Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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