Home Journals Articles Updates About
CN
image
收藏切换
Synthesis and anti-inflammatory activity of curcumin succinate prodrugs
收藏切换
PDF
Cheng NIU1, Dong-ge WANG1, Tian-hong ZHANG2, Hong-liang WEN1, *
Acta Pharmaceutica Sinica | 2018, 53(12) : 2085 - 2092
Less
收藏切换
Acta Pharmaceutica Sinica | 2018, 53(12): 2085-2092
• ORIGINAL ARTICLES Medicinal Chemistry •
Synthesis and anti-inflammatory activity of curcumin succinate prodrugs
Full
Cheng NIU1, Dong-ge WANG1, Tian-hong ZHANG2, Hong-liang WEN1, *
Affiliations
  • 1. School of Chemistry and Chemical Engineering, Beijing Institution of Technology, Beijing 102488, China
  • 2. Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing 100850, China
Published: 2018-12-12 doi: 10.16438/j.0513-4870.2018-0882
Outline
收藏切换

Curcumin, a polyphenolic compound from the plant Curcuma longa L., has shown a wide-spectrum of anti-inflammatory and antitumor activities. Despite the promising biological effects of curcumin, its poor solubility has restricted its use in the management of human ailments. To improve its water-solubility, curcumin succinate prodrugs were designed and synthesized and their aqueous solubility, stability, metabolism in rats and anti-inflammatory activity were evaluated (experiments had been approved by the ethics committee and carried out in accordance with the relevant guidelines and regulations; rats were provided by Beijing courtyard experimental animal center of Academy of Military Medical Sciences). The results showed that curcumin succinate prodrugs are very soluble in water and more stable than curcumin in water and in phosphate buffer solution. They released curcumin rapidly and quantitatively after intravenous administration. In phlogogen-induced paw edema in rats, curcumin succinate prodrugs showed anti-inflammatory activity as potent as dexamethasone.

curcumin  /  succinate  /  prodrug  /  anti-inflammatory
Cheng NIU, Dong-ge WANG, Tian-hong ZHANG, Hong-liang WEN. Synthesis and anti-inflammatory activity of curcumin succinate prodrugs[J]. Acta Pharmaceutica Sinica, 2018 , 53 (12) : 2085 -2092 . DOI: 10.16438/j.0513-4870.2018-0882
Appendix
Less
Year 2018 volume 53 Issue 12
PDF
166
70
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2018-0882
  • Receive Date：2018-09-28
  • Online Date：2026-01-15
  • Published：2018-12-12
Article Data
Affiliations
History
  • Received：2018-09-28
  • Revised：2018-10-30
Affiliations
    1. School of Chemistry and Chemical Engineering, Beijing Institution of Technology, Beijing 102488, China
    2. Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing 100850, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2018-0882
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House