Home Journals Articles Updates About
CN
image
收藏切换
Mechanisms of anti-inflammation of taurochenodeoxycholic acid based on network pharmacology
收藏切换
PDF
Lei LI1, Ba-ya-er TUMEN2, Pei-feng LI3, Chang LIU1, *, Sheng-he LI1, *, Kang-jian NING1, Jin-peng JIANG1
Acta Pharmaceutica Sinica | 2018, 53(12) : 2064 - 2075
Less
收藏切换
Acta Pharmaceutica Sinica | 2018, 53(12): 2064-2075
• Pharmacology •
Mechanisms of anti-inflammation of taurochenodeoxycholic acid based on network pharmacology
Full
Lei LI1, Ba-ya-er TUMEN2, Pei-feng LI3, Chang LIU1, *, Sheng-he LI1, *, Kang-jian NING1, Jin-peng JIANG1
Affiliations
  • 1. Key Laboratory of Quality and Safety Control for Pork, Ministry of Agriculture and Rural, College of Animal Science, Anhui Science and Technology University, Fengyang 233100, China
  • 2. Shanxi Animal Disease Control Center, Taiyuan 030027, China
  • 3. Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture and Rual, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China
Published: 2018-12-12 doi: 10.16438/j.0513-4870.2018-0600
Outline
收藏切换

To investigate the anti-inflammatory mechanisms of taurochenodeoxycholic acid (TCDCA), the molecule structure file of TCDCA was downloaded from PubChem database, PharmMapper and GeneCards were used to predict and screen the targets of TCDCA. STRING database and Cytoscape software were used to construct protein interactions network. GO and KEGG analysis was preformed through STRING database. The key targets were validated by molecular docking and the targets type was attributed by DisGeNET database. The network showed that 89 targets were involved in 68 biological processes including response to stimulus, multicellular organismal process, single-multicellular organism process, response to chemical, response to organic substance, by adjusting 51 signaling pathways, such as pathways in cancer, progesterone-mediated oocyte maturation, MAPK signaling pathway, proteoglycans in cancer. These findings provide an overview of anti-inflammation of TCDCA, which reflects the characteristic of multi-targets and multi-pathways of TCDCA. It pointed out the direction for further research on anti-inflammatory mechanism of TCDCA.

taurochenodeoxycholic acid  /  inflammation  /  network pharmacology  /  pharmacological mechanism  /  molecular docking
Lei LI, Ba-ya-er TUMEN, Pei-feng LI, Chang LIU, Sheng-he LI, Kang-jian NING, Jin-peng JIANG. Mechanisms of anti-inflammation of taurochenodeoxycholic acid based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (12) : 2064 -2075 . DOI: 10.16438/j.0513-4870.2018-0600
Appendix
Less
Year 2018 volume 53 Issue 12
PDF
115
37
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2018-0600
  • Receive Date：2018-07-01
  • Online Date：2026-01-15
  • Published：2018-12-12
Article Data
Affiliations
History
  • Received：2018-07-01
  • Revised：2018-07-31
Funding
Affiliations
    1. Key Laboratory of Quality and Safety Control for Pork, Ministry of Agriculture and Rural, College of Animal Science, Anhui Science and Technology University, Fengyang 233100, China
    2. Shanxi Animal Disease Control Center, Taiyuan 030027, China
    3. Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture and Rual, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2018-0600
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House