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Based on urine metabolomics to study effect of Liuwei Dihuang Wan on growth and development of rats
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Shu-yu KANG1, Jia-qi ZHANG1, Ai-jia ZHANG1, Ping WANG1, 2, *, Xi-jun WANG1, *
Acta Pharmaceutica Sinica | 2018, 53(10) : 1713 - 1720
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Acta Pharmaceutica Sinica | 2018, 53(10): 1713-1720
• Pharmaceutical Analysis •
Based on urine metabolomics to study effect of Liuwei Dihuang Wan on growth and development of rats
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Shu-yu KANG1, Jia-qi ZHANG1, Ai-jia ZHANG1, Ping WANG1, 2, *, Xi-jun WANG1, *
Affiliations
  • 1. Sino-America Chinmedomics Technology Collaboration Center, National TCM Key Laboratory of Serum Pharmacochemistry, Chinmedomics Research Center of State Administration of TCM, Laboratory of Metabolomics, Heilongjiang University of Chinese Medicine, Harbin 150040, China
  • 2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Published: 2018-10-12 doi: 10.16438/j.0513-4870.2018-0446
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On base of traditional physiological studies, building a comprehensive evaluation system for the efficacy of Liuwei Dihuang Wan (LW) for regulating the growth and development of rats by indicators that the overall metabolic profile and biomarkers of urinary metabonomics. Sixty-seven day-old Sprague-Dawley rats were randomly divided into four groups that are the control group and low-dose, medium-dose, and high-dose groups of LW. At the age of 28 days, different doses of LW extracts were continuously administered for 16 days. On the basis of behavior, body weight, organ index and femur length, a UPLC-HDMS technique was used to establish urine metabolomics method to characterize the profile of urine metabolism before and after intervention of LW, analysis and identificate related to drug effects of differential metabolism markers, and study the effect of LW on the growth and development of rats. LW could improve the overall behavioral ability of rats, promote weight gain and the growth of organs and bones, and 36 differential metabolites and 13 target metabolic pathways of urine under the intervention of LW were identified, and 8 metabolic markers were regarded as a key marker that LW effect the growth and development of rats. LW has a significant regulatory effect on the urine metabolic network during the growth and development of rats. This study interpreted the scientific implications of the effect of "Nourishing Kidney Yin" on the growth and development of rats.

Liuwei Dihuang Wan  /  the growth and development  /  metabolomics
Shu-yu KANG, Jia-qi ZHANG, Ai-jia ZHANG, Ping WANG, Xi-jun WANG. Based on urine metabolomics to study effect of Liuwei Dihuang Wan on growth and development of rats[J]. Acta Pharmaceutica Sinica, 2018 , 53 (10) : 1713 -1720 . DOI: 10.16438/j.0513-4870.2018-0446
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Article Info
doi: 10.16438/j.0513-4870.2018-0446
  • Receive Date：2018-05-14
  • Online Date：2026-01-15
  • Published：2018-10-12
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History
  • Received：2018-05-14
  • Revised：2018-07-16
Funding
Affiliations
    1. Sino-America Chinmedomics Technology Collaboration Center, National TCM Key Laboratory of Serum Pharmacochemistry, Chinmedomics Research Center of State Administration of TCM, Laboratory of Metabolomics, Heilongjiang University of Chinese Medicine, Harbin 150040, China
    2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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