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A new indole alkaloid from bulbils of Dioscorea opposite Thunb.
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Wei-sheng FENG1, 2, *, Meng-huan GUO1, 2, Yi-ge YIN1, 2, Yan-gang CAO1, 2, Cui-lan YANG1, 2, Yang-yang WANG1, 2, Man QI1, 2, Yan-li ZHANG1, 2, Ying-jie REN1, 2, Yan-ling LIU1, 2, Xiao-ke ZHENG1, 2
Acta Pharmaceutica Sinica | 2018, 53(7) : 1131 - 1133
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Acta Pharmaceutica Sinica | 2018, 53(7): 1131-1133
• ORIGINAL ARTICLES·Medicinal Chemistry •
A new indole alkaloid from bulbils of Dioscorea opposite Thunb.
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Wei-sheng FENG1, 2, *, Meng-huan GUO1, 2, Yi-ge YIN1, 2, Yan-gang CAO1, 2, Cui-lan YANG1, 2, Yang-yang WANG1, 2, Man QI1, 2, Yan-li ZHANG1, 2, Ying-jie REN1, 2, Yan-ling LIU1, 2, Xiao-ke ZHENG1, 2
Affiliations
  • 1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Published: 2018-07-12 doi: 10.16438/j.0513-4870.2018-0400
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This study was designed to study the chemical constituents from bulbil of Dioscorea opposite Thunb.. Four compounds were isolated by silica gel column chromatography. On the basis of physic-chemical characters and spectroscopic data analysis, these compounds were identified as lyzalkaloid (3, 4-dihydro-6-hydroxy-4-methyl-6H-pyrido[6, 5-b]indol-5(1H)-one) (1), anoectochine (2), ginsenine (3), and 2-hydroxy-3-(1H-indol-3-yl) propanoic acid methyl ester (4). Compound 1 is a new indole alkaloid, named as lyzalkaloid. Compounds 2-4 were isolated from this plant for the first time. The cytotoxic activities were assessed by MTT assay. All compounds exhibited the cytotoxic activity against HepG2 and MDA-231 with IC50 values of over 100 μmol·L-1, respectively. All compounds show no significant cytotoxic activities against HepG2, MDA-231 cancer cell.

Dioscorea L.  /  bulbils of Dioscorea opposite Thunb.  /  chemical constituent  /  indole alkaloid  /  cytotoxic activity
Wei-sheng FENG, Meng-huan GUO, Yi-ge YIN, Yan-gang CAO, Cui-lan YANG, Yang-yang WANG, Man QI, Yan-li ZHANG, Ying-jie REN, Yan-ling LIU, Xiao-ke ZHENG. A new indole alkaloid from bulbils of Dioscorea opposite Thunb.[J]. Acta Pharmaceutica Sinica, 2018 , 53 (7) : 1131 -1133 . DOI: 10.16438/j.0513-4870.2018-0400
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Year 2018 volume 53 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2018-0400
  • Receive Date：2018-05-02
  • Online Date：2026-01-15
  • Published：2018-07-12
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History
  • Received：2018-05-02
  • Revised：2018-05-29
Funding
Affiliations
    1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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