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Insights into structure and function of diterpene synthases in plants
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Yu-ru TONG1, 4, Wei GAO2, 3, *, Lu-qi HUANG4, *
Acta Pharmaceutica Sinica | 2018, 53(8) : 1195 - 1201
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Acta Pharmaceutica Sinica | 2018, 53(8): 1195-1201
• SPECIAL REPORTS •
Insights into structure and function of diterpene synthases in plants
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Yu-ru TONG1, 4, Wei GAO2, 3, *, Lu-qi HUANG4, *
Affiliations
  • 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 2. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • 3. Beijing Key Lab of TCM Collateral Disease Theory Research, Capital Medical University, Beijing 100069, China
  • 4. National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Published: 2018-08-12 doi: 10.16438/j.0513-4870.2018-0387
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Diterpene synthases from plants are key enzymes in diterpene biosynthesis, which catalyzed the initial cyclization cascade of (E, E, E,)-geranylgeranyl pyrophosphate, and generated diverse carbon skeletons. Recent research show that the structural and stereo chemical differences lead to diverse natural diterpene compounds of plants. The structures of diterpene synthases play a crucial role in cyclization function. This article mainly reviews the mechanisms, functional characteristics, and structural information of diterpene synthases according to the crystal structures and functions.

diterpene synthase  /  crystal structure  /  protein  /  mechanism  /  function
Yu-ru TONG, Wei GAO, Lu-qi HUANG. Insights into structure and function of diterpene synthases in plants[J]. Acta Pharmaceutica Sinica, 2018 , 53 (8) : 1195 -1201 . DOI: 10.16438/j.0513-4870.2018-0387
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Article Info
doi: 10.16438/j.0513-4870.2018-0387
  • Receive Date：2018-04-27
  • Online Date：2026-01-15
  • Published：2018-08-12
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History
  • Received：2018-04-27
  • Revised：2018-05-31
Funding
Affiliations
    1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
    2. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
    3. Beijing Key Lab of TCM Collateral Disease Theory Research, Capital Medical University, Beijing 100069, China
    4. National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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