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Research progresses in pharmacological effects of rhynchophylline and its isomers on nervous system
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Yan HUANG1, Wen-xia ZHOU1, *, Yong-xiang ZHANG1, Qin-shi ZHAO2
Acta Pharmaceutica Sinica | 2018, 53(7) : 1017 - 1022
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Acta Pharmaceutica Sinica | 2018, 53(7): 1017-1022
• SPECIAL REPORTS·Pharmacology of Chinese Medicine and Nervous Diseases •
Research progresses in pharmacological effects of rhynchophylline and its isomers on nervous system
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Yan HUANG1, Wen-xia ZHOU1, *, Yong-xiang ZHANG1, Qin-shi ZHAO2
Affiliations
  • 1. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
  • 2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Published: 2018-07-12 doi: 10.16438/j.0513-4870.2018-0250
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Uncaria rhynchophylla is one of the frequently used herbs in China, it is mainly used for heat-clearance, suppression of hyperactive liver, calming endogenous wind and arresting convulsion in traditional Chinese medicine (TCM). Alkaloids are the main active materials in Uncaria rhynchophylla, pharmacological studies have shown that Uncaria rhynchophylla and its alkaloids have comprehensive biological effects on the nervous system. Rhynchophylline is one of the most abundant alkaloids in Uncaria rhynchophylla. The recent studies demonstrate that rhynchophylline and its isomers (isorhynchophylline, corynoxine, corynoxine B) may be good drug candidates for treatment of Alzheimer's disease, Parkinson's disease, epilepsy, etc. Although the structures of the 4 alkaloids are very similar, they have different effects on nervous system. For example, corynoxine and corynoxine B exhibit better sedative effects than isorhynchophylline. Rhynchophylline and isorhynchophylline have been extensively studied. For development and utilization of rhynchophylline for nervous system disease, more studies are needed to unveil the structure-function relationship and the underlying mechanisms. Here, we summarizes the progresses the effects of rhynchophylline and its isomers on the nervous system.

Uncaria rhynchophylla  /  rhynchophylline  /  corynoxine  /  nervous system  /  Alzheimer's disease  /  epilepsy
Yan HUANG, Wen-xia ZHOU, Yong-xiang ZHANG, Qin-shi ZHAO. Research progresses in pharmacological effects of rhynchophylline and its isomers on nervous system[J]. Acta Pharmaceutica Sinica, 2018 , 53 (7) : 1017 -1022 . DOI: 10.16438/j.0513-4870.2018-0250
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Year 2018 volume 53 Issue 7
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doi: 10.16438/j.0513-4870.2018-0250
  • Receive Date：2018-03-22
  • Online Date：2026-01-15
  • Published：2018-07-12
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  • Received：2018-03-22
  • Revised：2018-04-17
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Affiliations
    1. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
    2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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