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Molecular mechanism of heat-clearing and detoxifying efficacy of Forsythia suspensa based on network pharmacology
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Xia SHEN1, *, Rong-rong XU1, Li-shan PEI1, Cong'e TAN1, *, Jun XU2, Yong-gang YAN1
Acta Pharmaceutica Sinica | 2018, 53(11) : 1834 - 1842
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Acta Pharmaceutica Sinica | 2018, 53(11): 1834-1842
• Pharmacology •
Molecular mechanism of heat-clearing and detoxifying efficacy of Forsythia suspensa based on network pharmacology
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Xia SHEN1, *, Rong-rong XU1, Li-shan PEI1, Cong'e TAN1, *, Jun XU2, Yong-gang YAN1
Affiliations
  • 1. School of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
  • 2. Department of Modern Chinese Medicine, Tianjin Pharmaceutical Research Institute, Tianjin 300193, China
Published: 2018-11-12 doi: 10.16438/j.0513-4870.2018-0577
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Forsythia suspensa is a herbal medicine that widely used for heat-clearing and detoxification in clinical practice. However, the molecular mechanism of its heat-clearing and detoxifying effect is still unclear. Based on the theory and methods of network pharmacology, the efficacy of the heat-clearing and detoxification of Forsythia suspensa was analyzed in this study. A total of 114 of compounds in Forsythia suspensa were collected, and 15 of effective compounds were obtained by analyzing the bioavailability (OB) and drug-like properties (DL). Then 26 corresponding targets were obtained using reverse pharmacophore-docking method. Using the BioGPS database, the organ location of the target initially was revealed. The compound-targetdisease network model of Forsythia suspensa was constructed by using the Cytoscape, which showed that the material basis of the heat-clearing and detoxification of Forsythia suspensa was to synthesize and synergize the effects by combining various active ingredients of multiple targets, simultaneously. This study explains the scientific mechanism of the heat-clearing and detoxification of Forsythia suspensa, and provides a theoretical foundation for clinical rational usage of Forsythia suspensa.

network pharmacology  /  Forsythia suspensa  /  detoxification  /  material basis  /  molecular mechanism
Xia SHEN, Rong-rong XU, Li-shan PEI, Cong'e TAN, Jun XU, Yong-gang YAN. Molecular mechanism of heat-clearing and detoxifying efficacy of Forsythia suspensa based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (11) : 1834 -1842 . DOI: 10.16438/j.0513-4870.2018-0577
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Article Info
doi: 10.16438/j.0513-4870.2018-0577
  • Receive Date：2018-06-21
  • Online Date：2026-01-15
  • Published：2018-11-12
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History
  • Received：2018-06-21
  • Revised：2018-07-31
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Affiliations
    1. School of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
    2. Department of Modern Chinese Medicine, Tianjin Pharmaceutical Research Institute, Tianjin 300193, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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