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Mechanism of glaucocalyxin A that induces apoptosis of glioma cell and up-regulates GEF-H1
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Fan FEI1, Xiao-gang JIANG1, Jian ZHANG1, Long-tai ZHENG1, Xue-chu ZHEN1, *, Ping GAN2, *
Acta Pharmaceutica Sinica | 2018, 53(11) : 1825 - 1833
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Acta Pharmaceutica Sinica | 2018, 53(11): 1825-1833
• Pharmacology •
Mechanism of glaucocalyxin A that induces apoptosis of glioma cell and up-regulates GEF-H1
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Fan FEI1, Xiao-gang JIANG1, Jian ZHANG1, Long-tai ZHENG1, Xue-chu ZHEN1, *, Ping GAN2, *
Affiliations
  • 1. College of Pharmacy, Soochow University, Suzhou 215021, China
  • 2. Taizhou Second People's Hospital, Taizhou 225500, China
Published: 2018-11-12 doi: 10.16438/j.0513-4870.2018-0533
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Rabdosia japonica(Burm.f.) Hara var.glaucocalyx(Maxim.) Hara is a traditional Chinese medicine, and is known to have anti-tumor effects. This study aims to investigate the effect of glaucocalyxin A (GLA), a diterpenoids extracted from Glaucocalyx Hara, on apoptosis of glioma cells and its mechanism. This study investigated the molecular signaling mechanism of GLA-induced glioma cell apoptosis by analyzing survival rate of C6 rat glioma cells, cell morphology, colony formation ability, interference ribonucleic acid, polymerase chain reaction, and Western blot. The result showed that in the presentce of GLA, the survival rate of C6 rat glioma cells decreased significantly, while the expression of guanine nucleotide-exchange factor-H1 was up-regulated, causing phosphorylation of extracellular regulated protein kinases proteins and apoptosis. Hence, the mechanism of GLA-induced glioma cell apoptosis was the GEF-H1/ERK pathway.

glaucocalyxin A  /  glioma  /  apoptosis  /  guanine nucleotide exchange factor-H1  /  extracellular regulated protein kinases
Fan FEI, Xiao-gang JIANG, Jian ZHANG, Long-tai ZHENG, Xue-chu ZHEN, Ping GAN. Mechanism of glaucocalyxin A that induces apoptosis of glioma cell and up-regulates GEF-H1[J]. Acta Pharmaceutica Sinica, 2018 , 53 (11) : 1825 -1833 . DOI: 10.16438/j.0513-4870.2018-0533
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Article Info
doi: 10.16438/j.0513-4870.2018-0533
  • Receive Date：2018-06-06
  • Online Date：2026-01-15
  • Published：2018-11-12
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  • Received：2018-06-06
  • Revised：2018-08-02
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    1. College of Pharmacy, Soochow University, Suzhou 215021, China
    2. Taizhou Second People's Hospital, Taizhou 225500, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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