Home Journals Articles Updates About
CN
image
收藏切换
Comparison study on the pharmacokinetic and tissue distribution of honokiol and its metabolites between normal and diabetic rats
收藏切换
PDF
Jun-jun WANG, Ling WANG, Xue-jin YU, Yong CHEN*
Acta Pharmaceutica Sinica | 2018, 53(6) : 987 - 992
Less
收藏切换
Acta Pharmaceutica Sinica | 2018, 53(6): 987-992
• Medicinal Chemistry Pharmaceutical Analysis •
Comparison study on the pharmacokinetic and tissue distribution of honokiol and its metabolites between normal and diabetic rats
Full
Jun-jun WANG, Ling WANG, Xue-jin YU, Yong CHEN*
Affiliations
  • Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei University, Wuhan 430062, China
Published: 2018-06-12 doi: 10.16438/j.0513-4870.2018-0011
Outline
收藏切换

This study was designed to compare normal and diabetic rats in the pharmacokinetic and tissue distribution of honokiol and its metabolites. Type 2 diabetic rat model was established using high-fat diet feeding for 6 weeks followed by single intraperitoneal injection of low dose (30 mg·kg-1) strepotozotocin. The concentration of honokiol and its metabolites were determined by high performance liquid chromatography. Pharmacokinetic parameters were calculated using DAS 3.0 software. The Cmax of honokiol in the normal rats and diabetic rats are 872.5 ±233.1 and 614.7 ±182.4 μg·L-1 respectively (P < 0.05), and the AUC are 3 827.2 ±926.9 and 3 004.7 ±391.4 μg·h·L-1 respectively. Meanwhile, AUC0-t and Cmax of the metabolite M2 were significantly increased in diabetic rats. The concentrations of honokiol in liver, kidney and brain in the diabetic model group were higher than those of the normal control group. Meanwhile, the exposure of M1 in liver, M2 in liver and kidney of the model group were higher than that in the normal group. The data suggest that the pharmacokinetics and tissue distribution of honokiol and its metabolites are changed in the pathological state of diabetes.

honokiol  /  diabetes  /  pharmacokinetic  /  tissue distribution
Jun-jun WANG, Ling WANG, Xue-jin YU, Yong CHEN. Comparison study on the pharmacokinetic and tissue distribution of honokiol and its metabolites between normal and diabetic rats[J]. Acta Pharmaceutica Sinica, 2018 , 53 (6) : 987 -992 . DOI: 10.16438/j.0513-4870.2018-0011
Appendix
Less
Year 2018 volume 53 Issue 6
PDF
132
58
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2018-0011
  • Receive Date：2018-01-04
  • Online Date：2026-01-15
  • Published：2018-06-12
Article Data
Affiliations
History
  • Received：2018-01-04
  • Revised：2018-03-21
Funding
Affiliations
    Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei University, Wuhan 430062, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2018-0011
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House