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Advances in models for predicting drug intestinal permeability
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Qing-qing SHEN1, 2, Zhen-zhou JIANG1, 2, 3, Lu-yong ZHANG2, 4, Xin HUANG1, 2, 3, *
Acta Pharmaceutica Sinica | 2018, 53(5) : 727 - 734
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Acta Pharmaceutica Sinica | 2018, 53(5): 727-734
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Advances in models for predicting drug intestinal permeability
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Qing-qing SHEN1, 2, Zhen-zhou JIANG1, 2, 3, Lu-yong ZHANG2, 4, Xin HUANG1, 2, 3, *
Affiliations
  • 1. Institute of Pharmaceutical Sciences, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
  • 2. Jiangsu Key Laboratory of Drug Screening, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
  • 3. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
  • 4. Center for Drug Screening and Pharmacodynamics Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
Published: 2018-05-12 doi: 10.16438/j.0513-4870.2018-0019
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Intestinal permeability is one of key factors determing absorption of oral drug products. It is a big challenge to assess permeability of compounds with high accuracy and high efficacy during research and development process. In this review, the principles, strengths, weaknesses and advances of common intestinal permeability models are summarized, with focus on Ussing chamber and parallel artificial membrane permeability assay. In addition, future trends of permeability models are briefly discussed. This review may provide a reference to accessing permeability of lead compounds.

intestinal permeability  /  single-pass intestinal perfusion in vivo  /  everted intestinal sac  /  Ussing chamber  /  Caco-2  /  parallel artificial membrane permeability assay
Qing-qing SHEN, Zhen-zhou JIANG, Lu-yong ZHANG, Xin HUANG. Advances in models for predicting drug intestinal permeability[J]. Acta Pharmaceutica Sinica, 2018 , 53 (5) : 727 -734 . DOI: 10.16438/j.0513-4870.2018-0019
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Article Info
doi: 10.16438/j.0513-4870.2018-0019
  • Receive Date：2018-01-05
  • Online Date：2026-01-15
  • Published：2018-05-12
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History
  • Received：2018-01-05
  • Revised：2018-01-31
Funding
Affiliations
    1. Institute of Pharmaceutical Sciences, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
    2. Jiangsu Key Laboratory of Drug Screening, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
    3. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
    4. Center for Drug Screening and Pharmacodynamics Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
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