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Advances on anti-neoplastic STAT3 inhibitors
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Yang ZOU1, Yuan LIU1, Wei HUANG1, 2, Jing-rong CUI1, Hong-wei JIN1, Liang-ren ZHANG1, Zhen-ming LIU1, *
Acta Pharmaceutica Sinica | 2018, 53(10) : 1598 - 1608
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Acta Pharmaceutica Sinica | 2018, 53(10): 1598-1608
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Advances on anti-neoplastic STAT3 inhibitors
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Yang ZOU1, Yuan LIU1, Wei HUANG1, 2, Jing-rong CUI1, Hong-wei JIN1, Liang-ren ZHANG1, Zhen-ming LIU1, *
Affiliations
  • 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
  • 2. Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
Published: 2018-10-12 doi: 10.16438/j.0513-4870.2018-0559
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Signal transducer and activator of transcription 3 (STAT3) is a kind of signal transduction protein involved in cell proliferation, differentiation, apoptosis and other important physiological processes in response to a large number of cytokines and growth factors in cells. It has been shown that constitutive activation of STAT3 is closely associated with oncogenesis and tumorigenesis. Inhibition of aberrant STAT3 signaling has been one of promising strategies for the development of anti-neoplastic therapeutics. The review summarizes the latest progress of STAT3 inhibitors in recent years from the perspective of targeting N-terminal domain, DNA binding domain, SH2 domain and C-terminal transactivation domain of STAT3.

signal transducer and activator of transcription 3  /  anti-tumor  /  inhibitor  /  DNA binding domain  /  N-terminal domain
Yang ZOU, Yuan LIU, Wei HUANG, Jing-rong CUI, Hong-wei JIN, Liang-ren ZHANG, Zhen-ming LIU. Advances on anti-neoplastic STAT3 inhibitors[J]. Acta Pharmaceutica Sinica, 2018 , 53 (10) : 1598 -1608 . DOI: 10.16438/j.0513-4870.2018-0559
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Article Info
doi: 10.16438/j.0513-4870.2018-0559
  • Receive Date：2018-06-14
  • Online Date：2026-01-15
  • Published：2018-10-12
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History
  • Received：2018-06-14
  • Revised：2018-07-09
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Affiliations
    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    2. Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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