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Mechanism of detoxification of Chebulae Fructus against Aconiti kusnezoffii radix toxicity based on network pharmacology
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Jian-liang LI1, Hui LIANG2, Shu-zhen CAI3, Zhi-yong LI4, Ya TU5, *
Acta Pharmaceutica Sinica | 2018, 53(10) : 1670 - 1679
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Acta Pharmaceutica Sinica | 2018, 53(10): 1670-1679
• Pharmacology •
Mechanism of detoxification of Chebulae Fructus against Aconiti kusnezoffii radix toxicity based on network pharmacology
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Jian-liang LI1, Hui LIANG2, Shu-zhen CAI3, Zhi-yong LI4, Ya TU5, *
Affiliations
  • 1. Medical Research Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China
  • 2. Mongolian Medicine College, Inner Mongolia Medical University, Huhehaote 010110, China
  • 3. Mongolian Medicine College, Inner Mongolia University of Nationalities, Tongliao 028000, China
  • 4. Pharmacy College of Minzu University of China, Beijing 100081, China
  • 5. Development Research Center of TCM, China Academy of Traditional Chinese Medicine, Beijing 100700, China
Published: 2018-10-12 doi: 10.16438/j.0513-4870.2018-0506
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The mechanism of detoxification of Chebulae Fructus against Aconiti kusnezoffii radix toxicity, which was known as Mongolian medical theory, was studied by establishing network of active components-targets-pathways of detoxification and enrichment analysis of targets and pathways based on network pharmacology. Firstly, the targets of active components collected from TCMSP and TCM Database@Taiwan were obtained through SwissTargetPrediction compared with disease targets from OMIM, TTD, DiGSeE. Then, the target enrichment analysis of GO functional annotations and KEGG pathways and protein function were analyzed by Metascape, furthermore, the action between main active ingredients and targets was assessed by SystemsDock Web Site. At last, the Cytoscape was used to construct the network of active components-targets-pathways. In conclusion, there were 15 components and 40 targets related to the cardiotoxicity caused by Aconiti kusnezoffii radix. Furthermore, Chebulae Fructus could regulate cardiac function to detoxify the toxicity by Aconiti kusnezoffii radix through the biological process of negative regulation of blood vessel diameter, regulation of ion transport circulatory system process, muscle contraction inorganic ion homeostasis and the pathways of neuroactive ligand-receptor interaction, calcium signaling pathway, adrenergic signaling in cardiomyocytes, etc.

Chebulae Fructus  /  Aconiti kusnezoffii radix toxicity  /  Mongolian medical theory  /  network pharmacology  /  mechanism
Jian-liang LI, Hui LIANG, Shu-zhen CAI, Zhi-yong LI, Ya TU. Mechanism of detoxification of Chebulae Fructus against Aconiti kusnezoffii radix toxicity based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (10) : 1670 -1679 . DOI: 10.16438/j.0513-4870.2018-0506
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Year 2018 volume 53 Issue 10
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Article Info
doi: 10.16438/j.0513-4870.2018-0506
  • Receive Date：2018-05-29
  • Online Date：2026-01-15
  • Published：2018-10-12
Article Data
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History
  • Received：2018-05-29
  • Revised：2018-07-04
Funding
Affiliations
    1. Medical Research Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China
    2. Mongolian Medicine College, Inner Mongolia Medical University, Huhehaote 010110, China
    3. Mongolian Medicine College, Inner Mongolia University of Nationalities, Tongliao 028000, China
    4. Pharmacy College of Minzu University of China, Beijing 100081, China
    5. Development Research Center of TCM, China Academy of Traditional Chinese Medicine, Beijing 100700, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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