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Network pharmacology-based study on mechanisms of Huanglian Jiedu Decoction impact on macrophage inflammation response
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Xia HENG1, 2, Bao-jie ZHU1, 2, Li-min SUN1, 2, Lin-mei PAN1, 2, Jin-ao DUAN1, 2, Qi-chun ZHANG1, 2, *, Hua-xu ZHU1, 2, *
Acta Pharmaceutica Sinica | 2018, 53(9) : 1449 - 1457
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Acta Pharmaceutica Sinica | 2018, 53(9): 1449-1457
• SPECIAL REPORTS •
Network pharmacology-based study on mechanisms of Huanglian Jiedu Decoction impact on macrophage inflammation response
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Xia HENG1, 2, Bao-jie ZHU1, 2, Li-min SUN1, 2, Lin-mei PAN1, 2, Jin-ao DUAN1, 2, Qi-chun ZHANG1, 2, *, Hua-xu ZHU1, 2, *
Affiliations
  • 1. Jiangsu Collaboration Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Jiangsu Province Key Laboratory of High Technology Research, Nanjing University of Chinese Medicine, Nanjing 210023, China
Published: 2018-09-15 doi: 10.16438/j.0513-4870.2018-0276
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This study was designed to explore the impact of Huanglian Jiedu Decoction (HLJDT) on macrophage inflammation reaction using the network pharmacology method. Glycolysis, sphingolipid metabolism and glutamine metabolism were also investigated for "multi-component, multi-target and multi-pathway", which supports a foundation for drug innovative research. The TCMSP database was used to screen the active components of HLJDT, the target protein predicted by PharmMapper database and the DAVID database for pathways annotation and analysis. The Cytoscape 3.2.1 software was used to construct the active componenttarget-pathway network map and GENEMANIA database for protein interaction analysis. System Dock Database Site is used in verification of molecular docking. The results showed that 84 active ingredients were screened in HLJDT with a total of 111 target targets. Fourteen pathways are affected according to 13 macrophage-related inflammatory proteins, and 8 pathways including 34 target proteins from glycolysis, sphingolipid metabolism and glutamine metabolism. Inflammation-related proteins and metabolism-related proteins can interact with each other through physical correlation, protein co-expression, etc. Berberine, baicalin and geniposide combined well with 5 important targets. Huanglian Jiedu Decoction may act on the glycolysis and sphingolipid pathways to regulate macrophage inflammatory responses.

network pharmacology  /  Huanglian Jiedu Tang  /  inflammation  /  metabolism
Xia HENG, Bao-jie ZHU, Li-min SUN, Lin-mei PAN, Jin-ao DUAN, Qi-chun ZHANG, Hua-xu ZHU. Network pharmacology-based study on mechanisms of Huanglian Jiedu Decoction impact on macrophage inflammation response[J]. Acta Pharmaceutica Sinica, 2018 , 53 (9) : 1449 -1457 . DOI: 10.16438/j.0513-4870.2018-0276
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Year 2018 volume 53 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2018-0276
  • Receive Date：2018-03-29
  • Online Date：2026-01-15
  • Published：2018-09-15
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History
  • Received：2018-03-29
  • Revised：2018-04-25
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Affiliations
    1. Jiangsu Collaboration Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Jiangsu Province Key Laboratory of High Technology Research, Nanjing University of Chinese Medicine, Nanjing 210023, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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