Home Journals Articles Updates About
CN
image
收藏切换
Pharmacological mechanism of Compound Xueshuantong in treatment of diabetic retinopathy based on network pharmacology
收藏切换
PDF
Yong-li SONG1, Zheng-lin WANG1, Wei XING1, Yan WU2, Wei WANG1, Jing HAN2, *
Acta Pharmaceutica Sinica | 2018, 53(9) : 1442 - 1448
Less
收藏切换
Acta Pharmaceutica Sinica | 2018, 53(9): 1442-1448
• SPECIAL REPORTS •
Pharmacological mechanism of Compound Xueshuantong in treatment of diabetic retinopathy based on network pharmacology
Full
Yong-li SONG1, Zheng-lin WANG1, Wei XING1, Yan WU2, Wei WANG1, Jing HAN2, *
Affiliations
  • 1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • 2. Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Published: 2018-09-15 doi: 10.16438/j.0513-4870.2018-0270
Outline
收藏切换

The aim of this study was to discover the pharmacological mechanism of Compound Xueshuantong in the treatment of diabetic retinopathy using network pharmacology. TCMSP software was used to search the active ingredients of Compound Xueshuantong, and the targets of its active ingredients were obtained. The targets of diabetic retinopathy were searched by OMIM, TTD, pharmGkb, DiGSeE and GAD database. The same 37 targets were analyzed by GO and KEGG using DAVID software. The results were verified using the SystemsDock. Cytoscape 3.6.1 software was used to establish an ingredient-target-pathway network model. Network pharmacological studies suggest that Compound Xueshuantong treated diabetic retinopathy through the vascular endothelial growth factor signaling pathways, mitogen-activated protein kinase signaling pathways and Toll-like receptor signaling pathways. Compound Xueshuantong alleviated diabetic retinopathy through multi-component, multi-target, and multi-pathway. This study provides a theoretical basis for further elucidation of the pharmacological mechanism of Compound Xueshuantong in the treatment of diabetic retinopathy.

network pharmacology  /  Compound Xueshuantong  /  diabetic retinopathy  /  target
Yong-li SONG, Zheng-lin WANG, Wei XING, Yan WU, Wei WANG, Jing HAN. Pharmacological mechanism of Compound Xueshuantong in treatment of diabetic retinopathy based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (9) : 1442 -1448 . DOI: 10.16438/j.0513-4870.2018-0270
Appendix
Less
Year 2018 volume 53 Issue 9
PDF
109
42
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2018-0270
  • Receive Date：2018-03-28
  • Online Date：2026-01-15
  • Published：2018-09-15
Article Data
Affiliations
History
  • Received：2018-03-28
  • Revised：2018-05-01
Funding
Affiliations
    1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
    2. Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2018-0270
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House