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Exploration into the mechanism of total flavonoids of Astragali Radix in the treatment of nephrotic syndrome based on network pharmacology
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Wang-ning ZHANG1, 2, Yao GAO1, 2, Ke LI1, 2, Jian-bin CHAO3, Xue-mei QIN1, 2, *, Ai-ping LI1, 2, *
Acta Pharmaceutica Sinica | 2018, 53(9) : 1429 - 1441
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Acta Pharmaceutica Sinica | 2018, 53(9): 1429-1441
• SPECIAL REPORTS •
Exploration into the mechanism of total flavonoids of Astragali Radix in the treatment of nephrotic syndrome based on network pharmacology
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Wang-ning ZHANG1, 2, Yao GAO1, 2, Ke LI1, 2, Jian-bin CHAO3, Xue-mei QIN1, 2, *, Ai-ping LI1, 2, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China
  • 3. Scientific Instrument Center, Shanxi University, Taiyuan 030006, China
Published: 2018-09-15 doi: 10.16438/j.0513-4870.2018-0251
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This study was designed to explore the mechanism of total flavonoids of Astragali Radix (TFA) in treating nephrotic syndrome through establishing the active components-targets network and protein-protein interaction (PPI) networks and analyzing the functions and pathways involved in the targets. The main active ingredients of TFA were obtained by 1H NMR and LC-MS, TCMSP and TCMID database. PharmMapper, SEA, SIB, HOME-NCBI-GENE, GeneCards and OMIM were used to predict and screen the active components of TFA. The Cytoscape software was used to construct the active components-targets network and protein-protein interactions network. The relation between the main active ingredients and targets were validated by Systems Dock Web Site. The GO and KEGG pathways involved in the targets were analyzed by ClueGO software. The target organ distribution was assigned by the BioGPS database. The results showed that 29 active components and 50 targets of TFA were screened and predicted. The network results showed that the TFA were mainly involved in biological processes such as inflammatory reaction process, oxidative stress process, apoptosis and autophagy, and played a role in the regulation of AGE-RAGE, PI3K/Akt, VEGF, IL-17 and MAPK signaling pathways to treat the nephrotic syndrome. This study reflects the characteristics of multi-components, multi-targets and multi-pathways of TFA, which provides new ideas and clues for further research on the mechanism of anti-nephrotic syndrome effects of TFA.

total flavonoids of Astragali Radix  /  nephrotic syndrome  /  network pharmacology  /  pharmacological mechanism  /  molecular docking
Wang-ning ZHANG, Yao GAO, Ke LI, Jian-bin CHAO, Xue-mei QIN, Ai-ping LI. Exploration into the mechanism of total flavonoids of Astragali Radix in the treatment of nephrotic syndrome based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (9) : 1429 -1441 . DOI: 10.16438/j.0513-4870.2018-0251
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Article Info
doi: 10.16438/j.0513-4870.2018-0251
  • Receive Date：2018-03-23
  • Online Date：2026-01-15
  • Published：2018-09-15
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History
  • Received：2018-03-23
  • Revised：2018-05-14
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China
    3. Scientific Instrument Center, Shanxi University, Taiyuan 030006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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