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Mechanism of Jiawei Foshou San on invasion and metastasis in endometriosis based on network pharmacology
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Ying ZHANG, Jia-hui WEI, Cheng-ling ZHANG, Pan-hong LI, Wen-wei SUN, Xiao-yu XU, Yi CHEN*
Acta Pharmaceutica Sinica | 2018, 53(9) : 1398 - 1405
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Acta Pharmaceutica Sinica | 2018, 53(9): 1398-1405
• SPECIAL REPORTS •
Mechanism of Jiawei Foshou San on invasion and metastasis in endometriosis based on network pharmacology
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Ying ZHANG, Jia-hui WEI, Cheng-ling ZHANG, Pan-hong LI, Wen-wei SUN, Xiao-yu XU, Yi CHEN*
Affiliations
  • College of Pharmaceutical Sciences and Chinese Medicine, Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine, Southwest University, Chongqing 400715, China
Published: 2018-09-15 doi: 10.16438/j.0513-4870.2018-0674
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Jiawei Foshou San is a new Chinese medicine compound consisting of ligustrazine, ferulic acid and fumarate. Previously Jiawei Foshou San inhibited the growth of endometriosis with unclear mechanism, especially in metastasis and invasion. In this study, network pharmacology analysis was performed to explore potential mechanism of Jiawei Foshou San on endometriosis. Jiawei Foshou San compound targets were purchase from TCMID, TCMSP and SEA database. Endometriosis targets were collected from OMIM, DisGeNET and GEO database. Networks of Jiawei Foshou San compound-compound targets and compound target-endometriosis target were established with Cytoscape 3.5.0 software. Key targets were analyzed for pathway enrichment through DAVID database. It was found that Jiawei Foshou San regulated 66 core targets (MMP2, MMP9, TIMP1, ICAM1, VEGFA, et al.) and affected 115 pathways, such as estrogen, HIF-1, TNF and GnRH signaling pathways. MMP-TIMP were uncovered as one cluster of the core targets. Furthermore, Jiawei Foshou San significantly suppressed the growth of ectopic endometrium. Meanwhile, invasion and metastasis were restrained after treating with Jiawei Foshou San through decreasing MMP-2 and MMP-9, increasing TIMP-1. In brief, these results provide a pharmacodynamic basis for the study of Jiawei Foshou San.

Jiawei Foshou San  /  endometriosis  /  network pharmacology  /  invasion and metastasis  /  mechanism
张莹, 韦佳慧, 张成玲, 李攀红, 孙文威, 徐晓玉, 陈怡. 基于网络药理学的加味佛手散抑制子宫内膜侵袭转移机制研究. 药学学报, 2018 , 53 (9) : 1398 -1405 . DOI: 10.16438/j.0513-4870.2018-0674
Ying ZHANG, Jia-hui WEI, Cheng-ling ZHANG, Pan-hong LI, Wen-wei SUN, Xiao-yu XU, Yi CHEN. Mechanism of Jiawei Foshou San on invasion and metastasis in endometriosis based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (9) : 1398 -1405 . DOI: 10.16438/j.0513-4870.2018-0674
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Year 2018 volume 53 Issue 9
553
274
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Article Info
doi: 10.16438/j.0513-4870.2018-0674
  • Receive Date：2018-07-24
  • Online Date：2026-01-15
  • Published：2018-09-15
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  • Received：2018-07-24
  • Revised：2018-08-02
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Affiliations
    College of Pharmaceutical Sciences and Chinese Medicine, Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine, Southwest University, Chongqing 400715, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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