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Effects of Z-9-octadecenyl-2-propanesulfonamide on the learning and memory function of diabetes-associated cognitive decline
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Cui-bao WANG1, Ying LI2, *, Hua-hui LU1, Nan-fu WEI1, Shuo HUANG1, Yun WANG1, Rong RAO1, Shu-zhen XU1, Tong REN3, *
Acta Pharmaceutica Sinica | 2018, 53(9) : 1504 - 1510
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Acta Pharmaceutica Sinica | 2018, 53(9): 1504-1510
• ORIGINAL ARTICLES •
Effects of Z-9-octadecenyl-2-propanesulfonamide on the learning and memory function of diabetes-associated cognitive decline
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Cui-bao WANG1, Ying LI2, *, Hua-hui LU1, Nan-fu WEI1, Shuo HUANG1, Yun WANG1, Rong RAO1, Shu-zhen XU1, Tong REN3, *
Affiliations
  • 1. Department of Anesthesiology, Xiamen Fifth Hospital, Xiamen 361000, China
  • 2. Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China
  • 3. Medical College, Xiamen University, Xiamen 361105, China
Published: 2018-09-12 doi: 10.16438/j.0513-4870.2018-0344
Outline
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This study was designed to investigate the therapeutic effect of novel compound Z-9-octadecenyl-2-propanesulfonamide (N15) on diabetes-associated cognitive decline (DACD). Type 2 diabetes (T2DM) mice models were established with multiple injection of low doses of streptozotocin (STZ) in mice on high fat diet (HFD). Vehicle and different concentrations of N15 (50 and 100 mg·kg-1·d-1) were administrated orally for 6 weeks. The step-down test, dark avoidance task and Morris water maze were conducted at the 6th week. The level of glucose and lactic acid in hippocampus were determined and mRNA of growth associated protein-43 (GAP-43), synaptophysin (SYN), brain derived neurotrophic factor (BDNF) and neurotrophins-3 (NT-3) in hippocampus were analyzed by real time PCR. The beneficial effects of N15 on learning and memory were found in the test of step-down, dark avoidance and Morris water maze. N15 reduced the level of glucose and lactic acid in hippocampus of HFD+STZ-induced diabetic encephalopathy model mice. Additionally, the mRNA expression of GAP-43, SYN, BDNF and NT-3 in hippocampus of HFD+STZ-induced diabetic encephalopathy mice were significantly increased by N15 (P < 0.01). These results suggest that the novel compound N15 can ameliorate diabetes-associated cognitive decline and the potential mechanism may be associated with the expressions of increased synaptic-related factors and neurotrophic factor in the hippocampus of diabetesassociated cognitive decline in mice.

Z-9-octadecenyl-2-propanesulfonamide  /  diabetic encephalopathy  /  hippocampus  /  neuroprotection
Cui-bao WANG, Ying LI, Hua-hui LU, Nan-fu WEI, Shuo HUANG, Yun WANG, Rong RAO, Shu-zhen XU, Tong REN. Effects of Z-9-octadecenyl-2-propanesulfonamide on the learning and memory function of diabetes-associated cognitive decline[J]. Acta Pharmaceutica Sinica, 2018 , 53 (9) : 1504 -1510 . DOI: 10.16438/j.0513-4870.2018-0344
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Year 2018 volume 53 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2018-0344
  • Receive Date：2018-04-13
  • Online Date：2026-01-15
  • Published：2018-09-12
Article Data
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History
  • Received：2018-04-13
  • Revised：2018-06-06
Funding
Affiliations
    1. Department of Anesthesiology, Xiamen Fifth Hospital, Xiamen 361000, China
    2. Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China
    3. Medical College, Xiamen University, Xiamen 361105, China
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