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Anti-oxidative protective effect and mechanism of klotho on ischemic brain injury
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Xin LI, Xue-qin YANG, Meng-qi SHI, Jun-rong DU*
Acta Pharmaceutica Sinica | 2018, 53(8) : 1331 - 1336
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Acta Pharmaceutica Sinica | 2018, 53(8): 1331-1336
• ORIGINAL ARTICLES •
Anti-oxidative protective effect and mechanism of klotho on ischemic brain injury
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Xin LI, Xue-qin YANG, Meng-qi SHI, Jun-rong DU*
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  • West China School of Pharmacy, Sichuan University, Chengdu 610041, China
Published: 2018-08-12 doi: 10.16438/j.0513-4870.2018-0328
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Present study was designed to investigate the effects and underlying antioxidant mechanism of klotho overexpression through an intracerebroventricular injection of a lentiviral vector that encoded murine klotho (LV-KL) on cerebral ischemia injury. Four weeks after the injection of lentivirus into the lateral ventricle of C57Balc/6J mice, a mouse model of global cerebral ischemia-reperfusion was established by bilateral common carotid artery occlusion (2VO). Klotho overexpression significantly improved neurobehavioral deficits and increased the number of survival neurons in the hippocampal CA1 and caudate putamen subregions. The overexpression also decreased malondialdehyde (MDA) content in brain, while mitochondrial manganese- superoxide dismutase (Mn-SOD) and catalase (CAT) expression in brain were increased. Moreover, klotho overexpression decreased Akt and forkhead box class O1 phosphorylation. These findings suggest that klotho may compensate for its aging-related decline to provide a promising therapeutic approach for the acute ischemic stroke during aging.

klotho  /  ischemic stroke  /  oxidative stress  /  Akt/FoxO1 signaling  /  aging
Xin LI, Xue-qin YANG, Meng-qi SHI, Jun-rong DU. Anti-oxidative protective effect and mechanism of klotho on ischemic brain injury[J]. Acta Pharmaceutica Sinica, 2018 , 53 (8) : 1331 -1336 . DOI: 10.16438/j.0513-4870.2018-0328
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doi: 10.16438/j.0513-4870.2018-0328
  • Receive Date：2018-04-11
  • Online Date：2026-01-15
  • Published：2018-08-12
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  • Received：2018-04-11
  • Revised：2018-05-07
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    West China School of Pharmacy, Sichuan University, Chengdu 610041, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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