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Absorption-enhancing mechanisms and advances of polymer-based supersaturated drug delivery system
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Shuang GONG1, Chun-liu ZHU2, 3, Jin-song DING1, Yong GAN2, *
Acta Pharmaceutica Sinica | 2018, 53(8) : 1310 - 1317
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Acta Pharmaceutica Sinica | 2018, 53(8): 1310-1317
• REVIEWS •
Absorption-enhancing mechanisms and advances of polymer-based supersaturated drug delivery system
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Shuang GONG1, Chun-liu ZHU2, 3, Jin-song DING1, Yong GAN2, *
Affiliations
  • 1. Xiangya School of Pharmaceutical Science, Central South University, Changsha 410000, China
  • 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 3. Engineering Research Center of Modern Preparation Technology of TCM, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2018-08-12 doi: 10.16438/j.0513-4870.2018-0159
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Supersaturated drug delivery systems (SDDS) are defined as systems that are able to generate and maintain a sustained drug supersaturation in the gastrointestinal tract, facilitating the oral absorption of drugs with poor water solubility. Supersaturated drug solution is generated from a higher energy form of the drug or rapid dissolution through various formulation options. However, supersaturated solution is a thermodynamically unstable system that can easily lead to drug precipitation, missing the aim of improving the absorption. Therefore, maintenance of the supersaturated state is essential for the development of SDDS. Polymer-based SDDS take polymers as the precipitation inhibitor, which can effectively prevent the precipitation of drugs, generating an excellent effect on maintenance of the stability of supersaturated solution. However, different polymers have distinct anti-precipitation ability, and the mechanisms of such activity supported by the polymer remain unrevealed. In this review, we summarize the research advances in the absorption-enhancing mechanisms and in vitro evaluations of polymers-based SDDS. This review provides a reference for the design of rational SDDS.

polymer  /  supersaturated drug delivery system  /  anti-precipitation  /  oral absorption
Shuang GONG, Chun-liu ZHU, Jin-song DING, Yong GAN. Absorption-enhancing mechanisms and advances of polymer-based supersaturated drug delivery system[J]. Acta Pharmaceutica Sinica, 2018 , 53 (8) : 1310 -1317 . DOI: 10.16438/j.0513-4870.2018-0159
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Article Info
doi: 10.16438/j.0513-4870.2018-0159
  • Receive Date：2018-02-26
  • Online Date：2026-01-15
  • Published：2018-08-12
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History
  • Received：2018-02-26
  • Revised：2018-03-21
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Affiliations
    1. Xiangya School of Pharmaceutical Science, Central South University, Changsha 410000, China
    2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    3. Engineering Research Center of Modern Preparation Technology of TCM, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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