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Recent advances in research and development of new small molecule immunosuppressants for inflammatory bowel disease
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Mei LI, Jian-zhuang MIAO, Shu XU*
Acta Pharmaceutica Sinica | 2018, 53(8) : 1289 - 1301
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Acta Pharmaceutica Sinica | 2018, 53(8): 1289-1301
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Recent advances in research and development of new small molecule immunosuppressants for inflammatory bowel disease
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Mei LI, Jian-zhuang MIAO, Shu XU*
Affiliations
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2018-08-12 doi: 10.16438/j.0513-4870.2018-0126
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Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder including mainly ulcerative colitis (UC) and Crohn's disease (CD). In China, IBD has become a common disease of the digestive system with an dramatic increase in incidence in recent years. The pathogenesis of IBD is not yet clear, and no drugs can completely cure IBD. Compared with monoclonal antibody drugs, small molecule drugs have the advantages of low cost, easy development as oral agents, and absence of immunogenicity. This review summarizes the recent research and development of small molecule immunosuppressants for IBD.

inflammatory bowel disease  /  ulcerative colitis  /  Crohn's disease  /  immunosuppressant  /  small molecule drug
Mei LI, Jian-zhuang MIAO, Shu XU. Recent advances in research and development of new small molecule immunosuppressants for inflammatory bowel disease[J]. Acta Pharmaceutica Sinica, 2018 , 53 (8) : 1289 -1301 . DOI: 10.16438/j.0513-4870.2018-0126
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Article Info
doi: 10.16438/j.0513-4870.2018-0126
  • Receive Date：2018-02-02
  • Online Date：2026-01-15
  • Published：2018-08-12
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  • Received：2018-02-02
  • Revised：2018-03-01
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Affiliations
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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