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Inhibitory effect of extratable petroleum ether of Polyrhachis vicina Roger on neuroinflammatory response in depressed rats
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Xin ZHANG1, Qian LONG1, Shi-feng CHU2, Sha-sha WANG1, Gui-ning WEI3, Dong-mei LI3, Nai-hong CHEN1, 2, *
Acta Pharmaceutica Sinica | 2018, 53(7) : 1042 - 1047
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Acta Pharmaceutica Sinica | 2018, 53(7): 1042-1047
• SPECIAL REPORTS·Pharmacology of Chinese Medicine and Nervous Diseases •
Inhibitory effect of extratable petroleum ether of Polyrhachis vicina Roger on neuroinflammatory response in depressed rats
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Xin ZHANG1, Qian LONG1, Shi-feng CHU2, Sha-sha WANG1, Gui-ning WEI3, Dong-mei LI3, Nai-hong CHEN1, 2, *
Affiliations
  • 1. College of Chinese Materia Medica, Shanxi University of Chinese Medicine, Taiyuan 030619, China
  • 2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 3. Guangxi Institute of Chinese Medicine and Pharmaceutical Sciences, Nanning 530022, China
Published: 2018-07-12 doi: 10.16438/j.0513-4870.2017-1010
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The main ingredient of extractable petroleum ether of Polyrhachis vicina Roger (EPPR) is octadecene unsaturated fatty acids.Mounting evidence supports that N-3 polyunsaturated fatty acids can attenuate neuroinflammation, reduce oxidative stress, then protect neurons.In order to explore the effect of EPPR on the inflammatory response of depressed rats, the model of depression was established by chronic unpredictable mild stress (CUMS).Sucrose preference test, forced swimming test were employed to investigate the anti-depressive effect of EPPR in rat.The activation of glial cells and astrocytes in the prefrontal cortex of depressed rats was observed by immunofluorescence.The levels of inflammatory factors were measured by Quantitative Real-time PCR.NF-κB was detected by immunoblotting.EPPR could significantly improve the depressive behavior of rats, decrease NF-κB translocation to the compartment of nucleus, down-regulate the pro-inflammatory cytokines IL-1β, TNF-α and indoleamine 2, 3-dioxygenase (IDO) gene expression levels, inhibit the activation of microglia and astrocytes in depressed rats.These results suggest that EPPR could notably ameliorate inflammation induced by chronic stress, and the protective effect might be linked to the regulation of NF-κB p65.

Polyrhachis vicina Roger  /  depression  /  cytokine  /  NF-κB p65
Xin ZHANG, Qian LONG, Shi-feng CHU, Sha-sha WANG, Gui-ning WEI, Dong-mei LI, Nai-hong CHEN. Inhibitory effect of extratable petroleum ether of Polyrhachis vicina Roger on neuroinflammatory response in depressed rats[J]. Acta Pharmaceutica Sinica, 2018 , 53 (7) : 1042 -1047 . DOI: 10.16438/j.0513-4870.2017-1010
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Year 2018 volume 53 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2017-1010
  • Receive Date：2017-10-16
  • Online Date：2026-01-15
  • Published：2018-07-12
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History
  • Received：2017-10-16
  • Revised：2017-11-20
Funding
Affiliations
    1. College of Chinese Materia Medica, Shanxi University of Chinese Medicine, Taiyuan 030619, China
    2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    3. Guangxi Institute of Chinese Medicine and Pharmaceutical Sciences, Nanning 530022, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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