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Research progress of SDF-1α/CXCR4 axis in the treatment of ischemic stroke with stem cells
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Xin ZHOU1, 2, Shi-feng CHU2, Jiang-fan WAN2, Chen CHEN2, Da-yong ZHANG1, *, Nai-hong CHEN2, *
Acta Pharmaceutica Sinica | 2018, 53(7) : 1054 - 1059
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Acta Pharmaceutica Sinica | 2018, 53(7): 1054-1059
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Research progress of SDF-1α/CXCR4 axis in the treatment of ischemic stroke with stem cells
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Xin ZHOU1, 2, Shi-feng CHU2, Jiang-fan WAN2, Chen CHEN2, Da-yong ZHANG1, *, Nai-hong CHEN2, *
Affiliations
  • 1. China Pharmaceutical University, Nanjing 210009, China
  • 2. Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2018-07-12 doi: 10.16438/j.0513-4870.2017-1007
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Stroke is the leading cause of death in Chinese currently, characterized by high incidence, high morbidity and high mortality, of which ischemic stroke accounted for 87%.However, it still lacks the ideal treatment.Stem cells are a class of cells with self-renewal ability and high differentiation potential.Stem cell transplantation breaks the irreversibility of nerve injury to post-stroke infarct area.However, stem cells also requiring specific chemokines to promote their directional migration to the injured tissue site after transplanted.Stromal cell-derived factor-1α (SDF-1α) is one of the typical chemokines.SDF-1α and its specific receptor CXCR4 can induce its migration, increase its proliferation and promote angiogenesis.In this paper, the role of SDF-1α/CXCR4 axis in the treatment of ischemic stroke in stem cells is reviewed in order to provide a theoretical basis for enhancing the efficacy of stem cell transplantation in the treatment of ischemic stroke.

ischemic stroke  /  stem cell  /  chemokine  /  stromal cell-derived factor-1α  /  chemokine (C-X-C motif) receptor 4
Xin ZHOU, Shi-feng CHU, Jiang-fan WAN, Chen CHEN, Da-yong ZHANG, Nai-hong CHEN. Research progress of SDF-1α/CXCR4 axis in the treatment of ischemic stroke with stem cells[J]. Acta Pharmaceutica Sinica, 2018 , 53 (7) : 1054 -1059 . DOI: 10.16438/j.0513-4870.2017-1007
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Article Info
doi: 10.16438/j.0513-4870.2017-1007
  • Receive Date：2017-10-16
  • Online Date：2026-01-15
  • Published：2018-07-12
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History
  • Received：2017-10-16
  • Revised：2017-12-18
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Affiliations
    1. China Pharmaceutical University, Nanjing 210009, China
    2. Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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