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Effect of cornel iridoid glycoside on PP2Ac phosphorylation in okadaic acid-induced neurotoxicity cells
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Cui-cui YANG1, Xue-xian KUAI1, 2, Li ZHANG1, Ya-li LI1, Lin LI1, *, Lan ZHANG1, *
Acta Pharmaceutica Sinica | 2018, 53(7) : 1036 - 1041
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Acta Pharmaceutica Sinica | 2018, 53(7): 1036-1041
• SPECIAL REPORTS·Pharmacology of Chinese Medicine and Nervous Diseases •
Effect of cornel iridoid glycoside on PP2Ac phosphorylation in okadaic acid-induced neurotoxicity cells
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Cui-cui YANG1, Xue-xian KUAI1, 2, Li ZHANG1, Ya-li LI1, Lin LI1, *, Lan ZHANG1, *
Affiliations
  • 1. Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing Engineering Research Center for Nerve System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
  • 2. Laboratory of Molecular Biology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Published: 2018-07-12 doi: 10.16438/j.0513-4870.2018-0188
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Alzheimer's disease (AD) is the most common neurodegenerative disease in the aging population.Abnormal hyperphosphorylation of tau is the main cause of AD.Protein phosphatases 2A (PP2A) can increase the hyperphosphorylation of tau.Cornel iridoid glycoside (CIG) is one of the main components extracted from Cornus of ficinalis.The aim of the present study was to investigate the effects and the underlying mechanisms of CIG on enhancing PP2A activity.SK-N-SH cells were exposed to 20 nmol·L-1 okadaic acid (OA, an inhibitor of PP2A) for 6 h to induce the hyper-phosphorylation of tau, in order to define the effect of CIG on the activity of PP2A and posttranslational modification of PP2A catalytic subunit C (PP2Ac).We found that OA significantly decreased PP2A activity, increased the phosphorylation of PP2Ac, and enhanced tau hyper-phosphorylation.Pre-incubation of CIG significantly attenuated the OA-induced tau hyper-phosphorylation at Ser 199/202 and Ser 396, and recovered the activity of PP2A.CIG inhibited PP2Ac phosphorylation at Tyr 307 and increased Src phosphorylation.In conclusion, the mechanism of CIG inhibition of tau hyper-phosphorylation was activation of PP2A to reduce the level of p-Src for a reduction of PP2Ac phosphorylation at Tyr307.

cornel iridoid glycoside  /  tau protein  /  protein phosphatase 2A  /  Src  /  Alzheimer's disease
Cui-cui YANG, Xue-xian KUAI, Li ZHANG, Ya-li LI, Lin LI, Lan ZHANG. Effect of cornel iridoid glycoside on PP2Ac phosphorylation in okadaic acid-induced neurotoxicity cells[J]. Acta Pharmaceutica Sinica, 2018 , 53 (7) : 1036 -1041 . DOI: 10.16438/j.0513-4870.2018-0188
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Article Info
doi: 10.16438/j.0513-4870.2018-0188
  • Receive Date：2018-03-05
  • Online Date：2026-01-15
  • Published：2018-07-12
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History
  • Received：2018-03-05
  • Revised：2018-04-01
Funding
Affiliations
    1. Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing Engineering Research Center for Nerve System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    2. Laboratory of Molecular Biology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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