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HMGB1 is involved into the anti-ischemic stroke effect of ginsenoside Rg1 in diabetic rats
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Shi-feng CHU1, Xin ZHOU1, Zhao ZHANG1, Chen CHEN1, Piao LUO1, 2, Nai-hong CHEN1, *
Acta Pharmaceutica Sinica | 2018, 53(6) : 958 - 965
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Acta Pharmaceutica Sinica | 2018, 53(6): 958-965
• Medicinal Chemistry Pharmacology •
HMGB1 is involved into the anti-ischemic stroke effect of ginsenoside Rg1 in diabetic rats
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Shi-feng CHU1, Xin ZHOU1, Zhao ZHANG1, Chen CHEN1, Piao LUO1, 2, Nai-hong CHEN1, *
Affiliations
  • 1. Institute of Materia Medica, Neuroscience Center, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
  • 2. College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
Published: 2018-06-12 doi: 10.16438/j.0513-4870.2018-0239
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Ginsenoside Rg1 is a common component of a variety of stroke and diabetes medications, but its anti-stroke effect in diabetic patients is unclear. The aim of this research is to test the therapeutic effect of Rg1 on ischemic stroke in diabetic rats, and elucidate the effect of Rg1 on post-stroke neuro-inflammation. Rg1 significantly reduced the infarct area percent, increased the behavioral score, and reduced the brain water content in diabetic rats after stroke in the diabetic rats. Rg1 reduced the post-stroke inflammatory response and decreased the expression of high mobility group box1 (HMGB1) protein significantly. Elevated level of HMGB1 activity by supplementing exogenous HMGB1 protein abolished the anti-stroke effect of Rg1, which suggests that HMGB1 is involved into the anti-stroke effect of Rg1 in the diabetic rats.

ginsenoside Rg1  /  ischemic stroke  /  diabetes mellitus  /  high mobility group protein  /  neuro-inflammation
Shi-feng CHU, Xin ZHOU, Zhao ZHANG, Chen CHEN, Piao LUO, Nai-hong CHEN. HMGB1 is involved into the anti-ischemic stroke effect of ginsenoside Rg1 in diabetic rats[J]. Acta Pharmaceutica Sinica, 2018 , 53 (6) : 958 -965 . DOI: 10.16438/j.0513-4870.2018-0239
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Article Info
doi: 10.16438/j.0513-4870.2018-0239
  • Receive Date：2018-03-19
  • Online Date：2026-01-15
  • Published：2018-06-12
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  • Received：2018-03-19
  • Revised：2018-04-16
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Affiliations
    1. Institute of Materia Medica, Neuroscience Center, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
    2. College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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