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Inhibitors of aquaporin 1 and its role in tumor development and progression
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Zhi-yu ZHANG, Juan WU, Xue-jun LI*
Acta Pharmaceutica Sinica | 2018, 53(6) : 910 - 919
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Acta Pharmaceutica Sinica | 2018, 53(6): 910-919
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Inhibitors of aquaporin 1 and its role in tumor development and progression
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Zhi-yu ZHANG, Juan WU, Xue-jun LI*
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  • School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China
Published: 2018-06-12 doi: 10.16438/j.0513-4870.2018-0066
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Aquaporin 1 (AQP1), the first water channel protein discovered among the aquaporin family, is a hydrophobic transmembrane protein involved in transcellular water movement. Recent evidence shows that AQP1 plays a role in tumor cell proliferation and migration, angiogenesis and tumor development and progression, representing a potential therapeutic target. In this review, we discuss the structures, functions and inhibitors of AQP1, as well as the involvement of AQP1 in tumor development and progression.

aquaporin 1  /  tumor proliferation  /  tumor cell migration  /  angiogenesis  /  inhibitor
Zhi-yu ZHANG, Juan WU, Xue-jun LI. Inhibitors of aquaporin 1 and its role in tumor development and progression[J]. Acta Pharmaceutica Sinica, 2018 , 53 (6) : 910 -919 . DOI: 10.16438/j.0513-4870.2018-0066
Year 2018 volume 53 Issue 6
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doi: 10.16438/j.0513-4870.2018-0066
  • Receive Date:2018-01-17
  • Online Date:2026-01-15
  • Published:2018-06-12
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  • Received:2018-01-17
  • Revised:2018-02-13
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    School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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