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Complicated intermolecular interactions formed between organofluorine and drug target
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Gui-min WANG1, 2, Zheng-dan ZHU1, 2, Zhao-qiang CHEN1, Zhi-jian XU1, Wei-liang ZHU1, 2, *
Acta Pharmaceutica Sinica | 2018, 53(5) : 701 - 708
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Acta Pharmaceutica Sinica | 2018, 53(5): 701-708
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Complicated intermolecular interactions formed between organofluorine and drug target
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Gui-min WANG1, 2, Zheng-dan ZHU1, 2, Zhao-qiang CHEN1, Zhi-jian XU1, Wei-liang ZHU1, 2, *
Affiliations
  • 1. CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 2. University of Chinese Academy of Sciences, Beijing 100049, China
Published: 2018-05-12 doi: 10.16438/j.0513-4870.2018-0013
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Fluorinated compounds, which now make up 20%-25% of all marketed chemical drugs, are playing significant role and showing great potential in medicinal chemistry. Fluorine substitution is always utilized to change the physicochemical properties of the compounds to improve the ADME/T properties. In addition, fluorine substitution leads to improvement of the ligand binding affinity. With respect to molecular level, organofluorine can form various intermolecular interactions with the target proteins, e.g., hydrogen bond, halogen bond, C-F…π interaction, polar interaction and so on. These interactions display unique properties or nature due to the specificity of fluorine atom, which are at the center of attention. This paper reviews the related research background, followed by the research progress of hydrogen bond, halogen bond, C-F…π interaction, polar interaction and some other interactions involved organofluorine.

organofluorine  /  weak intermolecular interaction  /  hydrogen bond  /  halogen bond  /  C-F…π interaction
Gui-min WANG, Zheng-dan ZHU, Zhao-qiang CHEN, Zhi-jian XU, Wei-liang ZHU. Complicated intermolecular interactions formed between organofluorine and drug target[J]. Acta Pharmaceutica Sinica, 2018 , 53 (5) : 701 -708 . DOI: 10.16438/j.0513-4870.2018-0013
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Article Info
doi: 10.16438/j.0513-4870.2018-0013
  • Receive Date：2018-01-04
  • Online Date：2026-01-15
  • Published：2018-05-12
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History
  • Received：2018-01-04
  • Revised：2018-01-23
Funding
Affiliations
    1. CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    2. University of Chinese Academy of Sciences, Beijing 100049, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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