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Research of berberine in treatment of depression
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Ya-nan SUN, Min LIU, Qi WANG, Chun-yue YU, Tai-ming WEI*
Acta Pharmaceutica Sinica | 2018, 53(12) : 2006 - 2011
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Acta Pharmaceutica Sinica | 2018, 53(12): 2006-2011
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Research of berberine in treatment of depression
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Ya-nan SUN, Min LIU, Qi WANG, Chun-yue YU, Tai-ming WEI*
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  • Daqing Campus of Harbin Medical University, Daqing 163319, China
Published: 2018-12-12 doi: 10.16438/j.0513-4870.2018-0593
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Depression is a common mental disorder. It is estimated that by 2020, the global incidence of depression will be about 20%, which will bring huge economic burden to society. The pathogenesis of depression is complicated, the diagnostic method is not objective, and the cure rate is low. Antidepressants are often associated with adverse reactions during treatment, and patient compliance is poor. Therefore, a single component with antidepressant effects in natural medicines or a compound Chinese medicine gradually shows an advantage in the treatment of depression. Berberine (C20H18NO4) is one of the main components of traditional Chinese medicine Coptis. In recent years, a large amount of evidence indicates that berberine has a good antidepressant effect on different animal models of depression, and its mechanism may be related to the regulation of monoamines and metabolism, anti-inflammatory and anti-oxidation in the brain. This article describes the antidepressant effect and mechanism of berberine, and provides a basis for further exploration and research on the antidepressant effect of berberine.

berberine  /  depression  /  monoamine neurotransmitter  /  inflammatory factor  /  oxidative stress
Ya-nan SUN, Min LIU, Qi WANG, Chun-yue YU, Tai-ming WEI. Research of berberine in treatment of depression[J]. Acta Pharmaceutica Sinica, 2018 , 53 (12) : 2006 -2011 . DOI: 10.16438/j.0513-4870.2018-0593
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doi: 10.16438/j.0513-4870.2018-0593
  • Receive Date：2018-06-28
  • Online Date：2026-01-15
  • Published：2018-12-12
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  • Received：2018-06-28
  • Revised：2018-07-23
Affiliations
    Daqing Campus of Harbin Medical University, Daqing 163319, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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