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Lead compound optimization strategy (6)-improving the plasma stability
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Xiao-wei WU, Jiang WANG, Hong LIU*
Acta Pharmaceutica Sinica | 2018, 53(2) : 192 - 201
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Acta Pharmaceutica Sinica | 2018, 53(2): 192-201
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Lead compound optimization strategy (6)-improving the plasma stability
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Xiao-wei WU, Jiang WANG, Hong LIU*
Affiliations
  • State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Published: 2018-02-12 doi: 10.16438/j.0513-4870.2017-0934
Outline
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Plasma stability plays an important role in the druggability of lead compound. Improving the plasma stability of compounds by structural modification can lead to good pharmacokinetic and pharmacodynamics properties. This review provides a summary of varieties of structure modification strategies for improving plasma stability including bioisosterism, increasing steric hindrance, ring closure, scaffold hopping and etc.

plasma stability  /  structural modification  /  lead compound  /  bioisosterism
Xiao-wei WU, Jiang WANG, Hong LIU. Lead compound optimization strategy (6)-improving the plasma stability[J]. Acta Pharmaceutica Sinica, 2018 , 53 (2) : 192 -201 . DOI: 10.16438/j.0513-4870.2017-0934
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Year 2018 volume 53 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2017-0934
  • Receive Date：2017-09-20
  • Online Date：2026-01-15
  • Published：2018-02-12
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History
  • Received：2017-09-20
  • Revised：2017-11-20
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    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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